Talk:NPM1

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Correction in function: I needed to correct this sentence in the function section which claimed the NPM1 protein is somehow carrying around ribosomes. I checked at the source and there is no such thing, that this small protein would transport entire ribosomes. So, I just corrected it according the citations. It is rather involved in the biogenesis of such larger structures, and in the process of transporting other proteins to the nucleolus. But if somebody really has evidence of that please revert to the old version. Thanks. —Preceding unsigned comment added by 92.106.153.17 (talk) 22:43, 27 March 2011 (UTC) And it makes sense. NPM1 binds to the p53 tumor suppressor protein and if a mutation occurs on that gene encoding for NPM1, or both alleles, assuming it is recessive and autosomal, it no longer has an affinity to this suppressor protein and can thereby be a factor in the genesis of some types of cancer (esp. leukemia). But with all derailing events, there have to be other mutations cooperating. One mutation alone on a single gene is hardly ever enough to bring about those factors that turn a normal cell into leukemia or tumor cell. —Preceding unsigned comment added by 92.106.153.17 (talk) 23:05, 27 March 2011 (UTC)[reply]