Talk:NESS-0327

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Ideal sources for Wikipedia's health content are defined in the guideline Wikipedia:Identifying reliable sources (medicine) and are typically review articles. Here are links to possibly useful sources of information about NESS-0327.

PubMed provides review articles from the past five years (limit to free review articles)
The TRIP database provides clinical publications about evidence-based medicine.
Other potential sources include: Centre for Reviews and Dissemination and CDC

Untitled

To be honest I'm kind of dubious about the 350 femtomolar affinity cited in the literature, its just so much higher than any normal ligand (with the exception of avidin-biotin of course) that it is the kind of claim that really calls for independent confirmation. Hopefully some more studies with this compound will confirm whether this figure is correct. Meodipt (talk) 12:53, 1 August 2008 (UTC)[reply]

Neutral Antagonism

This compound is not truly a neutral antagonist. The authors did not check whether their assay could actually detect inverse agonism, and a later study by Finlay et al. (DOI: 10.1002/prp2.901) showed that NESS-0327 is also an inverse agonist, like Rimonabant. 121.98.26.214 (talk) 03:04, 23 April 2024 (UTC)[reply]