Talk:Macrophage colony-stimulating factor

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Cytokine or chemokine?

According to my book ("Medizinische Mikrobiologie und Immunologie"; Hahn, Falke, Kaufmann, Ullmann; Springer-Verlag, Heidelberg, 5. Aufl., 2004; ISBN 3-540-21971-4) M-CSF is a chemokine, not a cytokine. Could someone more knowledgeable than me clarify on this one? 85.180.189.77 (talk) 06:59, 20 March 2012 (UTC)[reply]

I appologies in advance if I'm writting in the wrong place in an attempt to answer this. I'm new to commenting on wikipedia (but long term user) and unfamiliar with coding.

However, I'll try to answer your question, despite that almost two years have passed.

A good review of cytokines and chemokines can be found here: http://www.ncbi.nlm.nih.gov/pubmed/12592293 Just to summarise:

Cytokines are a broad cathegory of small secreted proteins that can cause proliferation, differentiation activation or inactivation of cells within the immune system. Chemokines are a subgroup of cytokines, that are involved in motility of immune cells. Thus, they are involved in chemotaxis and subsequent adhesion of the immune cells. Using this classification, I would argue that CSF-1 / M-CSF is a cytokine and cannot be classified as a chemokine(and so does the NCBI description http://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=1435. Why your book says otherwise, I do not know. I do not know it, but it does sound decent. I hope this helped?212.88.77.66 (talk) 10:38, 19 February 2014 (UTC)[reply]