Talk:Ligand-gated ion channel

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Untitled

This particular Ion Channel is now known as a Chemically gated Ion Channel.

Other ligand gated ion channels?

At the moment, this page focuses entirely on one type of ligand-gated ion channels, namely the extracellularly activated ligand-gated ion channel receptors (some are missing, e.g. histamine and proton gated ones). Should we change the title or add the missing classes of LGIC, such as IP3 and ryanondine receptors, cGMP gated channels etc.?

We should definitely make the coverage more complete, are there more that are missing?Momeara (talk) 12:47, 24 November 2013 (UTC)[reply]

There is a more complete list of LGICs in the navbox at the bottom of this article (see {{Ligand-gated ion channels}}). Histamine gated ion channels appear to be much less well characterized (see for example PMID 22192818). Finally the proton gated = acid-sensing ion channels (ASICs; a subclass of sodium channels) and already has its own article. It may be a semantic question as to whether ASICs should be classified as a ligand gated ion channels. In any case, please expand this article as you see fit. Boghog (talk) 13:53, 24 November 2013 (UTC)[reply]

ATP-gated channels

"ATP-gated channels open in response to binding the nucleotide ATP"

I have no medical background whatsoever, I'm a software engineer that happens to be interested in basic neurology. If I'm not mistaken, adenosine triphosphate is not a nucleotide (one of the 4/5 components of codons-amino acids-DNA/RNA). Adenosine is. While related, they are two different things.Crackettt (talk) 11:39, 19 March 2014 (UTC)[reply]

I also have no medical background, and also am interested in neuroscience, but I think you're mistaken, as a nucleotide is defined as consisting of a nitrogenous base, a sugar (ribose or deoxyribose) and one to three phosphate groups, which describes ATP. Just because nucleotides are components of DNA/RNA doesn't mean that's all they are. See the Encyclopaedia Britannica article on nucleotide.UnderEducatedGeezer (talk) 01:46, 12 December 2015 (UTC)[reply]

What exactly IS 'binding'? And how does it open the ion-pore?

What I mean is why/how does a neurotransmitter adhere to a receptor site, and why/how is it subsequently released?

And if I've even remotely correctly understood the immediate result of the binding, the neurotransmitter's presence causes protein folding of the receptor, which results in a shape change which opens the pore, in at least some cases by a twisting (or more like an un-twisting) action.UnderEducatedGeezer (talk) 12:00, 25 April 2016 (UTC)[reply]