Talk:Löfgren syndrome

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A note on the genetics

Two sentences involving the genetic association of DQB1*0201 and DRB1*0301. In almost all individuals, excepting rare occurrences in Africa and unlikely a subject of genetic associations the two loci are within the same haplotype.

This haplotype is part of the ancestral haplotype found in Europeans called AH8.1. It is composed of (using the new and approved nomenclature - see IMGT-HLA)

A*01:01-C*07:01-B*08:01-DRB1*03:01-DQA1*05:01-DQB1*02:01

There are other haplotypic variants, in Sardinia there is the

A*18:01-C*05:01-B*30:02-DRB1*03:01-DQA1*05:01-DQB1*02:01 haplotype that represents one of the highest frequency haplotypes for a people in the western world.

It is simpler and more accurate to say that there is an involvement of the DR3-DQ2.5 haplotype (see Celiac disease for a discussion of DQ2.5). Or in obsolete lingo HLA DR3-DQ2

You can verify the allele and haplotype frequencies using //www.allelefrequencies.net PB666 ^yap 20:31, 30 June 2011 (UTC)[reply]