Talk:John David Sinclair

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Successful in 80% Needs a Citation

"The Sinclair Method, which is simply taking an opioid antagonist before drinking, has been found to be successful in about 80% of Alcohol Use Disorder (AUD) sufferers."

The peer reviewed citations did not show anything like that.

Patient-centered care interventions for the management of alcohol use disorders: a systematic review of randomized controlled trials.vPablo Barrio, Antoni Gual.PMID: 27695301 PMCID: PMC5029836 DOI: 10.2147/PPA.S109641 "Naltrexone was not better than placebo in the supportive groups, but it had a significant effect in the coping groups: 27% of the coping/naltrexone patients had no relapses to heavy drinking throughout the 32 weeks, compared with only 3% of the coping/placebo patients." 108.45.134.208 (talk) 13:22, 11 April 2023 (UTC)[reply]

Whoever wrote the above is WAY off target and shows a fundamental misunderstanding of how TSM works.The Sinclair Method has a clinically proven success rate of 78%.

The clinical trials which showed that "Naltrexone was not better than placebo..." were the ones where patients took the medication whilst abstinent and therefore where pharmacological extinction wasn't possible.

The medication HAS to be used in the specific targeted dosage regime of The Sinclair Method, in order to be effective. The medication is very ineffective when taken with abstinence. 2.96.139.235 (talk) 15:39, 22 April 2023 (UTC)[reply]