Talk:Immortal DNA strand hypothesis

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A fact from Immortal DNA strand hypothesis appeared on Wikipedia's Main Page in the Did you know column on 2 October 2006. The text of the entry was as follows:

Did you know... that the immortal DNA strand hypothesis was proposed in 1975 by John Cairns as a mechanism for adult stem cells to minimize mutations in their genomes?

A record of the entry may be seen at Wikipedia:Recent additions/2006/October.

Wikipedia

Potential Epigenetic Implications

Strand immortality, if it occurs, could compromise epigenetic fidelity. I have recently published in "PLoSGenetics" a mathematical model to examine this possibility. Please see (Genereux 2009) for details. —Preceding unsigned comment added by Kale1674 (talk • contribs) 07:05, 6 June 2009 (UTC)[reply]

A counterexample to the hypothesis

I am no expert on stem cells but recently read this paper:

Steinhauser, M. L.; Bailey, A. P.; Senyo, S. E.; Guillermier, C.; Perlstein, T. S.; Gould, A. P.; Lee, R. T.; Lechene, C. P. Multi-Isotope Imaging Mass Spectrometry Quantifies Stem Cell Division and Metabolism. Nature 2012, 481 (7382), 516–519. https://doi.org/10.1038/nature10734.

There a different approach was used and no evidence supporting the immortal strand hypothesis were found. Could someone qualified please look at it and if found valid include it in the article? Furthermore, most cited papers are before 2010 and what is the current research opinion in 2023? 137.120.191.170 (talk) 15:00, 20 July 2023 (UTC)[reply]