Talk:Ifosfamide

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Ideal sources for Wikipedia's health content are defined in the guideline Wikipedia:Identifying reliable sources (medicine) and are typically review articles. Here are links to possibly useful sources of information about Ifosfamide.

PubMed provides review articles from the past five years (limit to free review articles)
The TRIP database provides clinical publications about evidence-based medicine.
Other potential sources include: Centre for Reviews and Dissemination and CDC

== Amide vs. amine ==

There are (at least) three Wikipedia articles about related substances:
ifosfamide
trofosfamide
cyclophosphamide
The systematic names given in the articles are as follows:
ifosfamide = N-3-bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-AMIDE-2-oxide
trofosfamide = N,N,3-tris(2-chloroethyl)-1,3,2-oxazaphosphinan-2-AMIDE 2-oxide
cyclophosphamide = N,N-bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-AMINE 2-oxide
(capitalization added for emphasis). The question here is why ifosfamide and trofosfamide are considered "amides" while cyclophosphamide is considered an "amine". None of these substances has the characteristic CONH2 group. Either they are all amines or they are all amides. Which one is correct? Thomas.Hedden (talk) 00:25, 21 June 2011 (UTC)[reply]

More on systematic name

The systematic name of ifosfamide is given as:
N-3-bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amide-2-oxide
Aside from the question of whether this should be considered an amide or an amine, shouldn't this be:
N,3-bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amide-2-oxide
That is, shouldn't there be a COMMA between the initial "N" and the "3" rather than a hyphen? Thomas.Hedden (talk) 00:57, 21 June 2011 (UTC)[reply]

"meanwell criteria"?

A Google search of this term yields only mirrors of this article. Can anyone elaborate about this? -- megA (talk) 19:27, 26 February 2014 (UTC)[reply]

Meanwell was the researcher who wrote quite extensively in the 1980s about ifosfamide in various diseases; some of his papers discuss neurotoxicity (e.g. doi:10.1016/0140-6736(90)90054-9 and doi:10.1016/S0140-6736(85)91432-1). I can't currently find the paper where his toxicity criteria are outlined, but I'm pretty sure that this is the reason why the criteria bear his name. JFW | T@lk 19:54, 26 February 2014 (UTC)[reply]

Thank you! -- megA (talk) 11:03, 27 February 2014 (UTC)[reply]

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ifosfamide MoA is not (directly) supported by reference #2

ifosfamide MoA is not support by reference #2 primarily; i.e., ref #2 cited 160+ references, one of which may support the MoA described. Further, the mechanism described is quite vague.

Thus, since ifosfamide is a prodrug for/of cyclophosphamide, I suggest merging with the cyclophosphamide wikpedia entry or linking to it and using the references cited in the cyclophosphamide entry to support additions to the ifosfamide entry's MoA subsection: Cyclophosphamide, and I suggest, as well, pulling refs from the wiki entry for the drug class itself. Riviello.michael (talk) 21:12, 25 March 2024 (UTC)[reply]