Talk:Hyperimmunoglobulin E syndrome

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how much IgE is considered to be hyper ?

This topic is in need of attention from an expert on the subject.

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i put the 'Expert-verify' tag in the article because the key information of what the normal levels of IgE are in ng/mL or kIU/L is missing. "> 10 times normal" is rather vague when neither this article nor Immunoglobulin E have a referenced value of the normal value or a normal range. Boud (talk) 22:38, 14 August 2008 (UTC)[reply]

|||Just a minor issue, but Job was given boils by God, not Satan. At least give credit to the right deity.|||

See Job 2.7--it was Satan, but by permission from God. Tarshizzle (talk) 23:07, 1 April 2012 (UTC)[reply]

HyperimmunoglobulinEMIA

The article title should read Hyperimmunoglobulinemia E Syndrome, as referenced http://www.ncbi.nlm.nih.gov/pubmed/17458437. Hyperimmunoglobulin is a word with no significance. — Preceding unsigned comment added by Cenayon (talk • contribs) 16:50, 6 October 2015 (UTC) Diddo, this needs to be moved EnviroHealth01 (talk) 21:43, 11 December 2015 (UTC)[reply]

I do not believe this is incorrect, the general concept of Hyperimmunoglobulinemia means a heightened immunoglobulin response and would not refer to the specific antibody. Hyper-IgE or Hyperimmunoglobulin E is specifically referencing the antibody IgE. It is Hyper as in the levels of this specific antibody. This is in line with the extensive literature on the subject

In summary, Hyperimmunoglobulinemia doesn't refer to IgE, IgA or IgM. Hyper-Immunoglobulin E, or Hyper-IgE is the correct reference to this specific class of disorders ^[1] --Xp fun (talk) 22:05, 4 August 2021 (UTC)[reply]

References

^ "Human Inborn Errors of Immunity: 2019 Update of the IUIS Phenotypical Classification" (PDF). J Clin Immunol (2020). 40: 66–81. doi:10.1007/s10875-020-00758-x.

Pathophysiology needs work

Pathopysiology needs work - this is a heterogeneous group of diseases with different genetic causes and biochemical mechanisms. Currently Pathophysiology says: "Abnormal neutrophil chemotaxis due to decreased production of interferon gamma by T lymphocytes is thought to cause the disease.[6][unreliable medical source][non-primary source needed]" Ref 6 is dated 2000; TYK2 gene was the first gene one found, in 2006 (only 2 published cases for that gene). Now 5 genes are known, with different mechanisms and effects. EnviroHealth01 (talk) 21:29, 11 December 2015 (UTC)[reply]

Move STAT3 / "Job's Syndrome" specifics to separate page?

Perhaps Autosomal Dominant HIES / HIES-AD / STAT3 / "Job's Syndrome" should be a separate page, which discusses its specific facial/dental/skeletal characteristics, leaving the HIES page to and differentiate between the 5 (or more) genetic plus any acquired causes and discuss any syndromic effects of chronically having IgE >2000. DIDS, PGM3 Deficiency, & Netherton Syndrome all already have specific pages. — Preceding unsigned comment added by EnviroHealth01 (talk • contribs) 21:37, 11 December 2015 (UTC)[reply]

Zaria Factor?

I can find no reference to to this, can we revert this change? Xp fun (talk) — Preceding undated comment added 23:13, 21 May 2022 (UTC)[reply]

[1] "Human Inborn Errors of Immunity: 2019 Update of the IUIS Phenotypical Classification" (PDF). J Clin Immunol (2020). 40: 66–81. doi:10.1007/s10875-020-00758-x.

[1]