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Talk:Huntington's disease/GA2

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GA Review

[edit]

I will be reviewing this article, so please expect a long list of constructive advice below. While I make my recommendations, could I quickly point out the following issues:

  •  Done The article currently does not follow the header names suggested by WP:MEDMOS.
  •  Done Several references (e.g. 79-84) are not templated. Others lack PMID, DOI or ISBN codes that would help the reader locate the source quickly.
These details have been filled up by numerous editors since review LeeVJ (talk) 15:03, 14 March 2009 (UTC)[reply]
  •  Done Some sections are very short, suggesting that they should either be expanded or merged with others.
Apart from BDNF which is new. LeeVJ (talk) 15:03, 14 March 2009 (UTC)[reply]

Here is the continued review:

Here we go then. I will provide individual comments that are each signed, so it is easy to keep track of what I have had to say and what the response may have been. JFW | T@lk 23:21, 14 August 2008 (UTC)[reply]

Garrondo has done an epic job of secondary rerefercing and weeding out unneccesary primaries. L∴V 00:04, 2 April 2009 (UTC)[reply]
  •  Done General: I was quite surprised to see no mention of Ian McEwan's excellent novel Saturday, in which HD plays a significant role and the literary description he makes is quite accurate. This is definitely not WP:TRIVIA. JFW | T@lk 23:21, 14 August 2008 (UTC)[reply]
  •  Done Intro: perhaps a bit more clinical information (which mental abilities are affected?) and slightly less hard scientific terminology. The intro needs to be as plain as possible, however fascinating CAG repeats are. JFW | T@lk 23:21, 14 August 2008 (UTC)[reply]
started LeeVJ (talk) 00:17, 20 October 2008 (UTC)[reply]
  •  Done Intro: I feel that every statement should be supported by a single source, unless that is genuinely impossible. WP:CITE applies to the entire article, which includes the intro. JFW | T@lk 23:21, 14 August 2008 (UTC)[reply]
bar first genetic test which is covered by another pointLeeVJ (talk) 13:23, 26 August 2008 (UTC)[reply]
  •  Done Signs and symptoms - Intro: comment on the difference between JHD and HD should probably be moved to the physical symptoms section. I have rewritten the section a bit, and the statement can readily be moved. JFW | T@lk 23:21, 14 August 2008 (UTC)[reply]
  •  Done Signs and symptoms - Physical: when do bradykinesia & dystonia occur? Instead of, or in addition to, the choreatiform movements? Can anything be said about their signifcance, or should they just be mentioned alongside the chorea? JFW | T@lk 23:21, 14 August 2008 (UTC)[reply]
Expanded description, think it is clearer now L∴V 00:28, 6 April 2009 (UTC)[reply]
  • Signs and symptoms - Physical: "slurring of speech" - can anything be said about the nature of the dysarthria? "Slurring" is nonspecific and could be bulbar, ataxic etc. JFW | T@lk 23:21, 14 August 2008 (UTC)[reply]
The wording slurring of speech does not appear any more in the article. What is left is "any function that requires muscle control is affected, resulting in physical instability, abnormal facial expression, and difficulties chewing, swallowing and speaking" Is it enough?--Garrondo (talk) 08:18, 2 April 2009 (UTC)[reply]
Done √ Sorry missed the question amongst the others - good point in that context I think it's ok L∴V 00:12, 6 April 2009 (UTC)[reply]
now referenced to Lancet. L∴V 01:47, 2 April 2009 (UTC)[reply]
Done: I have added: This occurs because instability is greater in spermatogenesis than oogenesis (obtained from lancet seminar)--Garrondo (talk) 08:18, 2 April 2009 (UTC)[reply]
Has been rereferenced, but I don't think anyone has had access to the ref suggested. L∴V 00:30, 2 April 2009 (UTC)[reply]
  •  Done Mechanism: there are several very short sections that could probably be merged. In general, I would discourage level 4 headers if it can at all be helped. JFW | T@lk 23:21, 14 August 2008 (UTC)[reply]
  •  Done Mechanism - Degradation: this needs rewriting. In particular, the model needs to be sourced to a secondary source (with optional retention of the most crucial primary sources only), and most of the concepts discussed need to be clarified in lay terms (e.g. "knockin mouse"). It's not easy, but it is crucial for readability. JFW | T@lk 23:21, 14 August 2008 (UTC)[reply]
Section has have several copyeditors and reduction in complexity. L∴V 00:30, 2 April 2009 (UTC)[reply]
  •  Done Mechanism - Other systems: I think this section is irrelevant, unless you can demonstrate that other organs are clinically affected in HD (not to my knowledge). JFW | T@lk 23:21, 14 August 2008 (UTC)[reply]
Expanded slightly, does seem to be emerging evidence, but the section might be better placed in research directions. LeeVJ (talk) 16:14, 14 March 2009 (UTC)[reply]
Section has been disbanded. L∴V 00:30, 2 April 2009 (UTC)[reply]

In conclusion, I think a large amount of work is still needed. I am particularly concerned about the fact that much information is inadequately sourced, and this is going to be an obstactle to GA unless this is addressed. I will try to help out if I can, but I have no access to the most promising secondary sources (the Bates/Harper/Jones book, the Imarisio and the Bonelli papers). Could I also point out a 2007 Lancet Seminar (doi:10.1016/S0140-6736(07)60111-1) that we really must cite prominently. JFW | T@lk 23:21, 14 August 2008 (UTC)[reply]

Comments on failing GAC. I feel uneasy about having to fail this once again, because so much excellent work has been done on it. It continues to receive much attention from some very dedicated editors, and I am in little doubt that it will reach GA status in the near future, and probably FA not much later. At present, however, there are some pretty significant impediments to GA. Most of them are outstanding issues that I listed above, such as the diversion into p53 in the "signs and symptoms" section. I'm also a bit surprised that the Lancet review I recommended was not used more often. Please keep me informed of signifant progress, and I will happily provide further input. JFW | T@lk 22:19, 27 August 2008 (UTC)[reply]