Talk:Glutaminase

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Localization

Does anyone know where glutaminase is localized in the cell? Is it soluble or membrane-bound? Where does the substrate come from (inside or outside the cell)? Where does the product go (inside or outside the cell)? —Preceding unsigned comment added by 63.125.124.226 (talk) 15:58, 16 December 2008 (UTC)[reply]

There are different forms of glutaminases, cytosolic ones and mitochondrial ones, as far as i know they are all not membrane-bound. The substrate glutamine is mostly imported from the extracellular space, where it represents the most abundand free amino acid. Nevertheless, glutamine can be produced by most cells. Since the reaction takes place inside the cell, the products are inside the cell as well, but of course they can be exported by the cells, but they do not have to... ('Galahadin (talk) 15:41, 5 March 2010 (UTC)',,)[reply]