Talk:Familial aortic dissection/GA1

GA Review

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Reviewer: Jmh649 (talk · contribs) 18:51, 29 April 2012 (UTC)[reply]

Comments

A couple of comments:

References need consistent formatting. Please see other good articles such as common cold to see how this is done.

Will comment more once this is addressed. --Doc James (talk · contribs · email) 18:51, 29 April 2012 (UTC)[reply]

Just in case, this essay says consistent formatting isn't a requirement (in the "mistakes to avoid" section). Biosthmors (talk) 22:03, 29 April 2012 (UTC)[reply]

I agree, citation formatting isn't a GA requirement, but it's nice to have them formatted consistently anyway, so I did so. Sasata (talk) 16:16, 30 April 2012 (UTC)[reply]

Part of this is to see if the student in question is going to address any of the concerns raised in this review. I check to make sure that references are appropriate. If they are not formatted properly doing so is much more difficult. My thanks to Sasata.Doc James (talk · contribs · email) 16:56, 30 April 2012 (UTC)[reply]

Further comments

Could use sections on Epidemiology, History, and Society and Culture as outlined at WP:MEDMOS.
With respect to "characteristics" these are not characteristics "There are various mechanisms by which the medial layers of the lumen are stressed and eventually torn.[9] Once torn these areas begin to fill with blood and become susceptible to aneurysm formation. Depending on the location of the tear, FAD normally affects the ascending or descending aorta, where the primary characteristic of a bulge can be seen. This bulge is the result of the creation of a false lumen due to the vast amount of blood seepage from the aortas and surrounding veins.[10] In some cases it is not uncommon to see degeneration in the ascending and descending aorta and the atrioventricular and semilunar valves due to elastolysis or breakdown and loss of elastic fibers. Mutations in, and or lack of genes encoding for connective tissue components such as collagens, and micro- fibril associated glycoproteins are believed to hold some responsibility for aortic breakdown among the layers comprising the lumen.[9]" Would be better in a section on pathophysiology. Characteristics means what sort of signs and symptom do people with the condition have. A brief discussion of the signs of connective tissue diseases would be good.
Per "Biomarkers lend a quick way to diagnose dissection when time is of the essence." the ref says "Future advances in this field include biomarkers in the early diagnosis of acute aortic dissection" and the paper says "Thus, we do not currently have an assay that has adequate sensitivity and specificity and allows an appropriate time window for the rapid diagnosis of acute aortic dissection." These markers are not typically used in clinical practice and this discussion belongs in a section on Research not one on diagnosis.
In the treatment section it refers to Type 1 and Type 2 FAD and the diagnosis section refers to Class 1 2 and 3. Are you referring to the Stanford and DeBakey classifications?
This content would probably be best merged into the article on aortic dissection as this is just one cause of this disease.

Will give editors some time to address these concerns.--Doc James (talk · contribs · email) 17:01, 30 April 2012 (UTC)[reply]