Talk:Dimethylaminopivalophenone

Also a DRI?

The forum I frequent had a member postulate that this compounds oxygen and nitrogen could interact in a near-minimum energy state which also would give it dopamine reuptake inhibition properties, noting that according to the reference, it was only tested for its affinity for the opioid G-coupled receptors and not as a dopaminergic indirect agonist. Nagelfar (talk) 23:03, 28 September 2015 (UTC)[reply]

Before article move:

It had this additional info:

"3-(dimethylamino)-2,2-dimethyl-1-phenylpropan-1-one (compound 29) Is a simple molecular structure & potent opioid analgesic (that overlays the seven to ten times stronger than pethidine compound 3,3-dimethyl propinyloxy piperidine but is not, as is the latter two, similarly a pro-drug like them; lacking for instance the toxicity of N-desmethyl pethidine) having a high TI ratio and requiring just a 1-step synthesis. It was discovered initially by Russian scientists in 1954 and subsequently rediscovered in the US in 1969. It's ED₅₀ is 16 mg/Kg (roughly double morphine sulfate under similar determining conditions) LD₅₀ is 238 mg/Kg.^[1]^[2]"

References

^ Analgetics. II. Relationship between structure and activity of some beta-amino ketones. J Med Chem. 1969 Nov;12(6):994-7.
^ Analgetics. II. Relationship between structure and activity of some beta-amino ketones (*.PDF hotlink)

Nagelfar (talk) 21:36, 2 October 2015 (UTC)[reply]

Fixed a bunch of stuff, added more resources and corrected the name. You got a completely wrong LD50, please read the resources instead of copying *gossip* on the internet. Aethyta (talk) 21:42, 2 October 2015 (UTC)[reply]

Meh, it's a *wiki* for a reason: we're in this together, thanks for the clean-up. Anything else omitted besides the corrected info in the above? Nagelfar (talk) 21:47, 2 October 2015 (UTC)[reply]

Conformal Isomerism

The important features of the prodine scaffold are all met by this compound. Is it worth mentioning that it's conformal isomerism that gives the compound it's shape rather than rigid compounds? — Preceding unsigned comment added by 81.99.74.135 (talk) 19:38, 12 January 2017 (UTC)[reply]

Conformal isomerism

Has anyone conducted a search using the title compound as a subset? Clearly one of the Ns overlays the N in pethidine. The conformational isomerism doesn't appeared to have been researched. It would only be of academic interest because to find out if replacing one N-Methyl with N-(n-propane)-3-aryl group. Either it's too wobbly to have any effects or, with only a small amount of conformal rigidity, it can bind more easily. If so, an F-18 marker would be valuable and, like phenoperidine, esters can form prodrugs hence long-duration. — Preceding unsigned comment added by 81.99.74.135 (talk) 15:30, 1 March 2017 (UTC)[reply]

[1] Analgetics. II. Relationship between structure and activity of some beta-amino ketones. J Med Chem. 1969 Nov;12(6):994-7.

[2] Analgetics. II. Relationship between structure and activity of some beta-amino ketones (*.PDF hotlink)

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