Talk:DNA clamp

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Untitled

Article merged: See old talk-page here

A fact from DNA clamp appeared on Wikipedia's Main Page in the Did you know column on 13 August 2006. The text of the entry was as follows:

Did you know... that DNA clamp proteins (pictured) keep the DNA polymerase replicating enzyme bound to the template DNA strand, increasing the rate of DNA synthesis up to 1,000-fold?

A record of the entry may be seen at Wikipedia:Recent additions/2006/August.

Wikipedia

Merger proposal

The following discussion is closed. Please do not modify it. Subsequent comments should be made in a new section. A summary of the conclusions reached follows.

The result was merge into DNA clamp. -- Sjodenenator (talk) 03:32, 25 February 2010 (UTC)[reply]

Support – DNA clamp is already a well established article that covers essentially the same material as in the beta clamp article. The main difference is that the material in the later is restricted to the prokaryotic polymerase III enzyme were as the former also covers the corresponding eukaryotic enzyme. Boghog (talk) 09:47, 31 January 2010 (UTC)[reply]
Support – Better for our readers to have it all in one article. Adrian J. Hunter^{(talk•contribs)} 03:56, 4 February 2010 (UTC)[reply]
Done - Just merged. Sjodenenator (talk) 03:14, 25 February 2010 (UTC)[reply]

The discussion above is closed. Please do not modify it. Subsequent comments should be made on the appropriate discussion page. No further edits should be made to this discussion.

Antibiotic Target?

Since the DNA clamp used by bacteria - the beta clamp - is so different from that found in eukaryotes (like humans), does it not follow that drugs could be made which specifically interfere with the functionality of the bacterial beta clamp that would not have any effect on DNA clamps in human cells? A drug that could drastically disrupt the speed with which bacteria can copy their DNA, and therefore the speed with which they can multiply, could have powerful antibiotic activity.

Has this been investigated at all? Spiral5800 (talk) 01:30, 29 December 2010 (UTC)[reply]

Topological equivalence of bacterial clamps

The three domains in a bacterial clamp are currently declared (without reference) to be 'topologically non-equivalent'. This is not true, and probably comes from incorrectly merging adjacent beta strands in secondary structure assignment (see the topology diagram at pdbsum, for instance). Inspecting the structure makes it clear that the topology is equivalent. --Quantum 7 10:50, 4 July 2014 (UTC)[reply]

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