Talk:DNA (cytosine-5)-methyltransferase 3A

	This article is within the scope of WikiProject Molecular Biology, a collaborative effort to improve the coverage of Molecular Biology on Wikipedia. If you would like to participate, please visit the project page, where you can join the discussion and see a list of open tasks.Molecular BiologyWikipedia:WikiProject Molecular BiologyTemplate:WikiProject Molecular BiologyMolecular Biology articles
???	This article has not yet received a rating on the importance scale.
	This article is supported by the Molecular and Cell Biology task force (assessed as Low-importance).

Possibly incorrect info in first paragraph on DNMT3a function

The second sentence of the function paragraph cites Rhee et al., 2000 and derives a strong claim from it. While interesting, the claim that loss of DNMT1 has a negligible effect on DNA methylation is most likely due to the fact that cell lines in both Rhee papers are not complete knockouts but rather a series of hypomorphs (partially functional truncated DNMT1 protein). This is outlined here: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1599915/. Further support for this is the essential nature of DNMT1 across mammalian cells: https://www.nature.com/articles/ng.3258 https://pubmed.ncbi.nlm.nih.gov/11137995/. It would be good for someone to check DEPMAP since this could be essential in a cell line specific manner, but generally the information is currently presented in a misleading way. 141.14.31.242 (talk) 12:16, 29 September 2024 (UTC)[reply]