Talk:Cystic fibrosis transmembrane conductance regulator

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Molecular Biology: Genetics / MCB

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Text and/or other creative content from this version of ΔF508 was copied or moved into Cystic fibrosis transmembrane conductance regulator with this edit on 15 March 2019. The former page's history now serves to provide attribution for that content in the latter page, and it must not be deleted as long as the latter page exists.

Untitled

The online book Genes and Disease has it right. In most tissues, transport of chloride ions by the CFTR is followed by movement of sodium ions in the same direction. --JWSchmidt 02:22, 2 October 2006 (UTC)[reply]

In the article Non-specific activation of the epithelial sodium channel by the CFTR chloride channel Nagel et al conclude, "Electrochemical coupling predicts that activation of CFTR then leads to a change in membrane potential and increased Na+ conductance, as indeed found by Reddy et al. (1999)," and also, "activated CFTR must lead.....according to the Goldmann–Hodgkin–Katz equation (Hille, 1992), to a voltage-dependent sodium conductance."
--JWSchmidt 02:59, 2 October 2006 (UTC)[reply]

Thank you - sounds good to me. --Arcadian 03:00, 2 October 2006 (UTC)[reply]

Is CFTR a pump or simply a channel???

I've been trying to determine this for quite a while. This article indicates, without citation, that through moving Cl- it produces a concentration gradient for Na and Water. This implies that it is able to move Cl against its concentration gradient, but I have not found evidence of this. There is a new article (http://www.pnas.org/content/107/3/959.short) called 'break a pump, make a channel' that has a great description of the channel in relation to its ABC ancestry. This article NEEDS to be summarized into this wiki, however I am still unable to answer the question of whether it is an active pump or just a channel. While it comes from a family of pumps, I think it is acting only as a channel. —Preceding unsigned comment added by UberMD (talk • contribs) 10:49, 28 February 2010 (UTC) It is classified as a channel. In fact it was originally thought of as a pump when it was first characterized but it is now regarded as a channel. SteveD 08-05-2010 07:12 a.m. —Preceding unsigned comment added by 122.106.219.138 (talk) 21:13, 7 May 2010 (UTC)[reply]

does CFTR transport Mg as well as Cl?

Hello, an anonymous user changed the text so that it says that magnesium ions are also conveyed through cell membranes, thanks to this protein, as seen in this diff.

I've fixed the formatting of the added link, but I don't know whether or not the content is accurate. Does anybody else know? Thanks, --Kyoko 21:35, 13 April 2007 (UTC)[reply]

That is an error, only chloride ions are conveyed through cell membranes via this pathway.—Preceding unsigned comment added by 139.80.7.95 (talk • contribs)

Thanks for fixing that. --Kyoko 23:09, 6 May 2007 (UTC)[reply]

Link number 3 Cystic_fibrosis_transmembrane_conductance_regulator#cite_note-pmid16934416-3reads as if these authors proved CFTR transports both Cl- and SCN-, while the article itself contains no actual data. I would suggest http://www.ncbi.nlm.nih.gov/pubmed/7681623 is both a more scientific (as in it presents actual data) and earlier reference providing evidence of SCN- and other anion transport via CFTR. — Preceding unsigned comment added by Sheldahl (talk • contribs) 16:57, 22 October 2013 (UTC)[reply]

Hello. It has been shown that CFTR in pancreatic ductal cells also conveys bicarbonate (see Choi JY and Muallem D. and Durie P et al. for updates).

The article gives the impression that the sweat test is somewhat obsolete. Far from it: the sweat test continues to be at the forefront of diagnostic tests for CF, in individuals.

200.12.130.80 (talk) 13:30, 10 November 2008 (UTC)[reply]

paracellular sodium current

The article mentions that sodium ions traverse the paracellular pathway in order to balance the electrical gradient. Is it possible there is one (or more) outwardly-rectifying sodium channels located on the apical membrane? Ktsharp (talk) 04:52, 13 July 2010 (UTC)[reply]

Structure

I think it should be more obvious that only for the first nucleotide binding domain (268 of the 1480) a crystal structure is known and that therefor the 1XMI structure image should not be in the box. Yak90 (talk) 10:51, 10 December 2013 (UTC)[reply]

Is it possible to measure (in living humans) the physiology of cell functions attributable to the CFTR gene?

Is it possible to measure (in living humans) the physiology of cell functions attributable to the Cystic fibrosis transmembrane conductance regulator (CFTR) gene?

The CFTR gene codes for a protein that conducts chloride and thiocyanate ions across epithelial cell membranes. Humans with two Delta F 508 mutations of this gene suffer from Cystic Fibrosis. I am interested in the physiology of heterozygous CF carriers who have one copy of the Delta F508 mutation. Do such people suffer any symptoms or diminished functions, perhaps as subtle symptoms of Cystic Fibrosis?

Are there laboratory tests available today that can evaluate the physiology of humans how have one copy of the Delta F508 mutation? Thanks! --Lbeaumont (talk) 13:07, 7 March 2015 (UTC)[reply]

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