Talk:Cyclic neutropenia

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Article categorization

This article was initially categorized based on scheme outlined at WP:DERM:CAT. kilbad (talk) 02:29, 24 June 2009 (UTC)[reply]

Comments

This should not redirect to neutropenia. Cyclic neutropenia is a specific entity within the overall heading of neutropenia.

I would like to find out more information on cyclic neutropenia. There doesn't seem to be much on the net about it. I have a 3 year old step-granddaughter with it and a biological grandchild on the way. I know it has the potential to become one of several forms of leukemia, but aside from that, nothing. Anybody with more information? We recently discovered the mother has type B Rh+ blood. Her daughters type is unknown. My son's type is O Rh+. I love them all and would like to know how I can help them, what to expect, and mostly if there's a possibility that my grandchild might be born with this disease.Materbean (talk) 03:00, 30 April 2009 (UTC)[reply]

Prognosis

Thank you for expanding this article, Miki Filigranski. May I ask where you sourced "without [G-CSF] ... there is a very high risk of life-threatening infections and death at an early age"? I've read most of the cited source (PMID 21595885) but couldn't find that. Adrian J. Hunter^{(talk•contribs)} 11:26, 13 August 2019 (UTC)[reply]

Adrian J. Hunter, it is sourced by part: "The natural risk of life-threatening invasive infections is very high. In the 1950s, almost all patients with the most severe form of the disease, with permanent and profound neutropenia, died in the first 2 years of life from sepsis, cellulitis or pneumonia; this was the case of 11 of the 14 patients in Kostmann's pedigree [2]. Two deaths from pneumonia were reported among 16 patients with cyclic neutropenia [188], while no deaths were reported among patients with chronic benign neutropenia [34, 142]. In the sixties and seventies, with more extensive used of antibiotic therapy, lethal sepsis became less frequent even in the most severe forms of congenital neutropenia. The report of Kostmann's pedigree in 1975 showed long-term survival [33] and prior the G-CSF period (since the ninety's) death from infections is already exceptional in such category of patients but occasionally is described even cyclic neutropenia [5].". Probably something like that can be found in other RS. The part of "early age" is additionally supported by the previously cited claim that "symptoms tend to improve in adulthood". I also personally know a case of a child with CyN who died several years ago of sepsis because was not treated with G-CSF. I think it's good to notice it because some patients don't get diagnosed with CyN, the ANC is alright due to cycles, and as such, as far I read, if they are not known and followed it seems to be hard to have an exact statistical number of people who died in a specific period of time.--Miki Filigranski (talk) 11:51, 13 August 2019 (UTC)[reply]

The source [5] of "occasionally is described even cyclic neutropenia [5]" leads to 1996 study (PMID 8989458), in which "four children in three of the nine [studied] families died of Clostridium or E. coli colitis, documenting the need for urgent evaluation of abdominal pain. Misdiagnosis with other neutropenias was common...". That's a high number for such a small sample.--Miki Filigranski (talk) 12:26, 13 August 2019 (UTC)[reply]