Talk:Collapsin response mediator protein family

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Three students from Boston College are working on editing this page for the benefit of the Society for Neuroscience. Our professor Joseph Burdo assigned this. Information on the class assignment can be found on the BI481 Fall 2012 page.

The three students are Paul Lavadera, Grace Kwak, and Brian Ford.

Peer Review for User:Neurojoe

This entry provides a lot of useful information on the subject of CRMPs particularly in the structure and the mechanisma of expression.

There are several minor critiques I would like to first mention. In many instances, the writing is wordy and could be condensed with less "fluff" and phrases like "neuronal polarity of neurons" should be edited for redundancies. Also, in the structure section it is mentioned that Ca2+ and Mg2+ stabilize CRMP-2. It would be useful to mention how or why this is observed. In that same section, it should be mentioned that the transcription factors noted (noggin, chordin etc.) are upregulated during brain development as mentioned in Schmidt & Strittmatter (2007)^[1]. This fact is hinted at but should be expressed more directly.

The article mentions that CRMPs have a crucial role in axonal death in several neurodegenerative diseases, but that it is also linked to neural growth and regeneration after injury. It would be useful to link these two phenomena together more deliberately as in Hou, Jiang & Smith (2008) ^[2] and talk about the mechanism of regeneration. While this phenomena is mentioned in the article it can be elaborated upon.

^ Schmidt EF, Strittmatter SM (2007). ""The CRMP family of proteins and their role in Sema3A signaling"". Advances in experimental medicine and biology. 600: 1–11. doi:10.1007/978-0-387-70956-7_1. PMID 17607942.
^ Hou ST, Jiang SX, Smith RA (2008). "Permissive and repulsive cues and signaling pathways of axonal outgrowth and regeneration". International review of cell and molecular biology. 267: 125–181. doi:10.1016/S1937-6448(08)00603-5. PMID 18544498.{{cite journal}}: CS1 maint: multiple names: authors list (link)

Mannintg (talk) 03:11, 19 November 2012 (UTC)[reply]

Thanks for the comment! Redundancies found in the article were omitted and CRMP's involvement in regeneration was incorporated in 'expression' section. In the same section, we've written that "CRMP-2 expression is induced by neuronal differentiation promoting factors such as noggin, chordin, GDNF, and FGF" to highlight what the authors (Schmidt and Strittmatter) were mostly concerned about: the regulation, particularly the induction of CRMP2. You might have misred the original reference because it says, during brain development, transcription factors which promote differentiation upregulate CRMP2 expression, not the other way around. Kwakg (talk) 09:40, 2 December 2012 (UTC)[reply]

We appreciate the review! Thanks for your comment about Ca2+ and Mg2+, as when looking more thoroughly for their roles in enchancing the stability of CRMPs we learned that these cations are simply speculated as stabilizing CRMP2. It is primarily on-going research right now so we decided to delete this information from the article to eliminate any ambiguity and confusion. Fordbd1 (talk) 10:07, 2 December 2012 (UTC)[reply]

Review

First thing I would like to point out is to put your citations at the end of the sentence rather than in the middle of a sentence and breaking it up. The correct way is to put all of the citations from a sentence at the very end. In your history section you mention a specific scientist who discover CRMP-2, make sure you cite where you got this for the sentence as you are stating a fact that you got from a source.

Also, in your structure section you state that CRMP-5 is only 50% homologous, homologous to what? Each one of the other CRMPs or to the consensus sequence of the other 4 CRMP alignments? Good job using the table format to get across what CRMPs are associated with what function, much easier to read. Lastly, make sure you link things such as Sema3A signaling cascade. This has a wikipedia page and should be linked to it in order to make it easier to jump from page to page. AdamMJenks (talk) 14:23, 29 November 2012 (UTC)[reply]

Thanks for the input Adam. The error in regards to homology has been fixed. Fordbd1 (talk) 20:37, 29 November 2012 (UTC)[reply]

As you have advised, in-citations in history section were re-checked and inserted. Also, hyperlinks were corrected and added in section Axonal growth cone guidance. Following Brian's mention about Sema3A, there is a link for Sema3A, the protein, but not for the Sema3A signaling cascade. And I don't think there is a page for SEMA3A gene. Thanks for the advice! Kwakg (talk) 06:49, 2 December 2012 (UTC)[reply]

[schmidt-1] Schmidt EF, Strittmatter SM (2007). ""The CRMP family of proteins and their role in Sema3A signaling"". Advances in experimental medicine and biology. 600: 1–11. doi:10.1007/978-0-387-70956-7_1. PMID 17607942.

[hou-2] Hou ST, Jiang SX, Smith RA (2008). "Permissive and repulsive cues and signaling pathways of axonal outgrowth and regeneration". International review of cell and molecular biology. 267: 125–181. doi:10.1016/S1937-6448(08)00603-5. PMID 18544498.{{cite journal}}: CS1 maint: multiple names: authors list (link)

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