Talk:Clobazam/Archive 1

Archive 1

Oral galenics because of insolubility in water?

"Clobazam is available in oral form only, due to its insolubility in water."

Well, apart from midazolam HCl and zolazepam HCl, all other common benzodiazepines (e.g. diazepam, lorazepam, clonazepam) are insoluble or very poorly soluble in water. Yet there are also parenteral galenics -- these substances are usually dissolved in mixtures of propyleneglycol, ethanol and polyethyleneglycols. So, I don't think that the reason for the absence of liquid parenteral galenics of clobazam is its poor water solubility.... Rather, there is no real need to have such galenics. With Midazolam, Diazepam, Lorazepam and Clonazepam Injections, most clinical indications for benzodiazepine medication are covered... Simple as that.--84.163.108.65 14:29, 8 May 2007 (UTC)

Clutter

Please stop cluttering the benzodiazepines with a collection of refs to arbitrary pubmed articles. Those are largely reports of some experiments, which have been carried out sometime, somewhere and for some reason on rats, mice and brain slices. For almost every such article you will find a match which comes to contrary conclusions. Please limit the contribution to agreed conclusions, as found in pharmacology books and the FDA profiles, avoid anecdotal reports, speculative results, could have, may be involved, has one time been observed, is suspected, is being investigated, could have a theoretical connection etc. Not everything which has sometimes been suspected, investigated, speculated or observed is relevant to pharmacology and should be included. Avoid bot-like inclusion of search results. pubmed is not a source but an Augias-Stable of unfinished research and a playground for students. Example: You conclude that chlordiazepoxide "is related" to quinazolines, by being investigated together with quinazolines in one citation. You conclude that it is a hapten, by being mentioned in an article about immuno assay tests. These are not relevant articles for pharmacology. Of course it is a hapten in an immuno assay test! That is how antibody based immuno assays work! But this has nothing to do with its pharmacology. Please limit yourself to agreed facts, like the FDA profiles. And the intention was NOT vandalism, but to arrive at something which looks more like the FDA fact sheet. Example: You claim as a peer reviewed fact the HIGH abuse liability of Chlordiazepoxide, because it is mentioned in a drug abuse article. FDA says low-to-medium abuse liability, placement in Schedule IV. You have largely used the same edit pattern on this article. You claim clobazam is neurotoxic, by showing neurotoxicity in some animal experiment etc. I propose that this article ends up looking like a FDA fact sheet, or a chapter from a pharmacology teaching book, not like an aggregation of random excerpts from arbitrary and unrelated pubmed abstracts. —Preceding unsigned comment added by 70.137.178.160 (talk) 23:22, 1 April 2008 (UTC)

Tell ya what anon user, lets try and compromise. Tell me what parts of the clobazam article that you have a problem with and I will try to work this out and come to an agreement, even though I haven't made very many edits to this article. This has gone on long enough. Lets all calm down. I know that we can come to some sort of an agreement on this.--Literaturegeek (talk) 01:44, 6 April 2008 (UTC)

Flag errors on Clobazam page

My name is Julia Simonsen, and I work for H Lundbeck A/S as Medical Information Specialist. My intent is to provide referenced and accurate information to the editors of Wikipedia for their use in Lundbeck related articles in order to help ensure that Wikipedia has the correct and latest information. Please see my user page JuliaSimonsen for information regarding my intentions for engagement on Wikipedia in alignment with their conflict of interest. Thank you.

I would like to flag the following errors on this page. In the US Onfi Package Insert (http://www.accessdata.fda.gov/drugsatfda_docs/label/2013/202067s002,203993s002lbl.pdf), Please find information for: Name, Bioavailability, Protein binding,

Section: Medical Uses Second paragraph: end os last sentence ‘…the treatment of seizures associated with Lennox-Gastaut Syndrome’ (Per Onfi Package insert) suggest to change to read: “adjunctive treatment of seizures associated with Lennox-Gastaut syndrome (LGS) in patients 2 years of age or older”

Section: Availability (Per Onfi Package insert) Please remove as clobazam is slightly soluble in water

Section: Side Effects: Suggest to be inline with the Package insert and present as clinical trial experience and Post-Marketing Experience

Pharmacology In the sentence ‘In a double-blind placebo-controlled trial published in 1990 comparing it to clonazepam, 10 mg or 20 mg of clobazam was shown to be much less sedating than either 0.5 mg or 1 mg of clonazepam Please remove ‘20mg’ as only 10mg was shown to cause less sedation in the reference

In the sentence ‘The ω1-receptor, which is found on the α1 subtype of the GABAA receptor, was shown to be responsible for the sedative effects of diazepam by McKernan et al. in 2000…’ Please ‘remove ω1-receptor’ since Alpha1 subunit on GABAa receptor was shown to be responsible for the sedative effects, as per reference

Throughout this section omega should be replaced with alpha

Overdose Suggest to change text in this section, so it is in line with the US Onfi Package insert — Preceding unsigned comment added by JuliaSimonsen (talk • contribs) 13:28, 5 November 2015 (UTC)