Talk:Cell–cell interaction

Untitled

I am improving the page for a class project under the supervision of User: tbohrer74 at Waynesville High School. Kbassett1995 (talk) 14:09, 5 March 2013 (UTC)

Article Structure

Hello, I think that some of the structure for the article can be derived from the lead section (introduction). The following two sections can describe stable interactions (i.e. cell junctions) and temporary or transient interactions. For the latter, two good example are the immune system and coagulation. There could be an additional section discussing the role of cell-cell interactions in development and a section on disease (i.e. bacterial infection and metastasis). For example, during metastasis, cells detach from their tumor site and attach to sites in distant tissues. Nguych01 (talk) 17:32, 13 March 2013 (UTC)

I agree with your ideas for organization. We can subcategorize the cell junctions section with adhesion and communication. Also, within the transient interactions, I think we should include bacterial. I saw you included a reference about them. I wonder if we need to mention cell matrix interactions? That isn't technically a cell-cell interaction so I don't want to get off topic since I think this page will have a lot of info. I guess we can see how it goes. Laurenwking (talk) 20:27, 13 March 2013 (UTC)

Comments from Dugalmaguire

Hi Nguych01, Hi Laurenwking. This is a tough one. There is definitely a lot of material to cover and as Laurenwking said, it is probably easy to stray off topic, but you've done a good job of keeping the information targeted as well as writing from a neutral point of view. I like the divisions between the types of cell interactions (i.e. stable/transient). It may be worth having a major division between prokaryotic and eukaryotic cells. The Voloshin paper on bacterial interactions has some nice information on different metabolites and the phenotypic response of surrounding cells. This could be compared to eukaryotic cell signalling, i.e. paracrine, synaptic, hormonal (I know you mention Ca in the gap junction section), then maybe a quick mention of signal transduction pathways, receptors, but that may be a slippery slope of off topic information. One other thing that would be helpful are pictures of different cell interactions, particularly of the stable junctions. Dugalmaguire (talk) 16:16, 10 April 2013 (UTC)

Comments from bmesido1

The lead section for this topic can expand both the content and context. It does not explain why the topic is notable and inadequately summarizes the most important points. Also, the lead section does not convey the importance of cell-cell interactions. The writers should expand the Stable Interactions definition by adding one or two more sentences. At present, this section is bare and does elaborate the cited source. However, the overall writing is concise and easy to understand. There is one misspelling in the subtitled section labeled, “Cell interactions between bacteria” within the Transient Interactions section; the writer misspelled the word through. Additionally, I would add more topics to enhance the topic of cell-cell interaction and these topics include: cell signaling, intracellular signaling and cell surface receptors. Bmesido1 (talk) 04:03, 12 April 2013 (UTC)

Great suggestions, I added further clarification and context to the lead section as well as expanded on "stable interactions" which hopefully improves the flow of the article. Cell signaling has importance in cell-cell interactions; however, I think a brief mention of it would be sufficient as I don't want to stray too far from the topic. Nguych01 (talk) 23:34, 24 April 2013 (UTC)

I agree, great suggestions bmesido1 and dugalmaguire! I added more to transient interactions under immune system and added a disease section under pathological implications. I am working on finding more images to enhance the page as well.I agree with Nguych01 that we only need a brief mention of cell signaling since that has its own detailed page. Laurenwking (talk) 01:23, 26 April 2013 (UTC)

Great revision of your article! The image is great, and the information is better organized and more developed than before. I think there is still some room for you to include more information about cell-signalling and how it is an important part of cell-to-cell interaction. We've got some of the same issues with our article: watch out for repeating references, they can be reduced to a single link and dead (red) links should also be removed. I changed the wording of the first 'Anchoring junction' sentence, it was a little awkward. I look forward to future revisions. Great job. Dugalmaguire (talk) 14:46, 27 April 2013 (UTC)

Comments from Klortho

• Link cell junctions in the lead.
• The body of the article could use more links. For example, apical surface → Cell_membrane#Membrane_polarity, occludin, claudin, etc. Most proteins and genes can be linked, and it adds a lot of value to the article to do so, I think.
• On the whole, this article looks very good!
• Could you possibly find another figure or two? I think, especially topics related to cell junctions could benefit.
• There seems to be a lot of overlap between this article and Cell junction. I think, it would be nice to put "main page" links in from, for example, "Anchoring Junctions" here to Cell_junction#Anchoring_Junctions (see Wikipedia:Summary_style, under "this page in a nutshell"). In some cases, it looks like you have more or better detail than they have over there, so it might be appropriate to put a {{Sync}} template in one or both places. (If you do that on the Cell junction page, make sure you mention it in your final project summary, so you can get credit for it.)

Klortho (talk) 01:38, 25 April 2013 (UTC)

Thanks for the input. I am working on finding more images but I am having trouble finding ones that aren't copyrighted. I am not sure what you meant by the sync template. When I clicked on the link it wasn't very helpful. Could you please explain? Thank you! Laurenwking (talk) 01:24, 26 April 2013 (UTC)

Don't worry about the sync template -- it doesn't matter. Klortho (talk) 02:07, 26 April 2013 (UTC)

Comments from Vdiaz3

Great job so far guys. I like the sections and subsections divisions which make the information much more manageable for the reader. Some observations:

• Citations or footnotes in the introduction are not needed as long as the material is covered and discussed in the body of the article (which you do for some of the material there).
• Perhaps in the introduction where you use the word “interactions” frequently and so close together you could probably use another word in place of in order to avoid redundancy.
• I would recommend adding one or two more relevant images that enhance the information. Maybe even a micrograph of some sort displaying and pointing out some real life cell-cell adhesion.
• If you are citing information from the same source several times one sentence after another, you can just have the footnote at the end of the paragraph rather than after every sentence in that paragraph such as in your cancer subsection and disease subsection paragraphs (with footnotes 2 and 10 respectively) and in other places throughout the article as well.
• No mention of specifics of plant cell-cell interactions are made. I recommend pointing out some of these specifics about plant cells in particular. For example, how in their case adhesion is facilitated by their cell walls and not transmembrane proteins like those involved in gap junctions (http://www.ncbi.nlm.nih.gov/books/NBK9851/). Also, plasmodesmata junctions in plant cells is relevant.
• You touch upon paracrine signaling and endocrine signaling. Maybe synaptic signaling could be included as well.
• Dissolved gasses such as NO in particular are getting a lot of attention lately. It could be worth looking into and possibly including.

Vdiaz3 (talk) 23:11, 2 May 2013 (UTC)

Thanks for the feedback; it was very helpful! I removed the citations in the introductions and also removed redundant citations within the paragraphs. I also tried to reduce the frequency of the "interactions" in the opening paragraph but it was a bit tricky. You were right and plant cell interactions needed to be included. I am still working on more images and adding synaptic signaling. Thank you again!Laurenwking (talk) 22:08, 8 May 2013 (UTC)

Thanks for the great suggestions, Vdiaz3! I went ahead and included an additional image. I also expanded on synaptic signaling in the "Receptor proteins in Direct-Contact Signaling" section. This is an especially important example of cell-cell interactions. Thanks for bringing it up. Nguych01 (talk) 16:13, 9 May 2013 (UTC)

Comments from tbrownc1

The article overall is pretty good and includes a lot of useful information. The structure and format is also easy to follow. IThe suggestions I have to improve your article are as follows:

• The last sentence of the introduction/ lead section should perhaps be including the first section.
• Citations are not needed in the leading section because the information should be used and cited in another section of the article also.
• Link vertebrates in the Gap Junction section.
• Link proteins, carbohydrates, and lipids in the Receptor proteins in Direct-Contact Signaling
• Only capitalize the first letter of the first work for section of titles/headings

Thanks for pointing that out. I went ahead and changed the appropriate capitals to lowercases. Nguych01 (talk) 16:49, 9 May 2013 (UTC)

• If possible, the addition of another image would be nice.

Tbrownc1 (talk) 00:05, 3 May 2013 (UTC)

Thank you for your feedback. I changed the introduction a bit and my partner linked the words you mentioned. I am working on addtional images. Laurenwking (talk) 22:09, 8 May 2013 (UTC)