Talk:Captopril

"Side effects"

Reach4theCapillaries, you're correct in saying that this is not my personal page. I am merely trying to ensure that this page is concise and accurate. In saying that, I fail to understand your insistence on adding the following paragraph under the heading "Side effects":

"Cough is a common side effect of Captopil, as it is with all the ACE inhibitors. Hypotension is also a possible side effect, if the dose is too high. Hyperkalemia is possible because sodium loss increases as potassium loss decreases, due to captopril having an inhibitory action on aldosterone. Because of captopril's short half-life, 2-3 times daily dosing can result in lack of patient compliance."

But okay, so I understand that you wish to discuss adverse effects (against my initial reservation). Therefore, on 10 May 2006, I combined the key points from your paragraph (with spelling, style and grammatical fixes) with my original paragraph. Evidently you didn't read this, and simply reinserted your own paragraph accusing me of reverting your edit. Today I have edited your addition again, and before you again accuse me of reverting you, please take note of the following points which explain my edits:

1. The correct term is "adverse effect" or "adverse drug reaction", not "side effect"; (see 2.)
2. Hypotension is not a side effect but it is an adverse effect – note that the two terms mean different things;
3. Captopril does not have an "inhibitory action" on aldosterone, but it does decrease angiotensin II levels which in turn decreases aldosterone levels (possibly leading to hyperkalaemia);
4. Short half-life, resulting in compliance issues, is neither adverse effect nor side effect.

-Techelf 14:19, 22 May 2006 (UTC)

What information is available for the use of Captopril in Rheumatoid Arthritis? Stephen 16:13 30 July 2007

Biopiracy?

Is this comment really necessary? It's a bit of a stretch to go from "using snake venom to kill things" to "antihypertensive drug."68.105.72.35 (talk) 06:40, 7 February 2011 (UTC)

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