Talk:C1-inhibitor

Physiology Mid‑importance

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Molecular Biology: MCB

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Pharmacology Mid‑importance

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Medicine Mid‑importance

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Assessment comment

The comment(s) below were originally left at Talk:C1-inhibitor/Comments, and are posted here for posterity. Following several discussions in past years, these subpages are now deprecated. The comments may be irrelevant or outdated; if so, please feel free to remove this section.

Comment(s)

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General remarks:

- Synonyms for C1-inhibitor should be included, as many exists.

- An additional figure is suggested: schematic representation of C1-inh, showing secondary structure elements in primary sequence. This is also suggested for other protein articles, too.

- The database informations should be shortened and cleaned up. Many are ambiguous and irrelevant, and even dead links exists.

- Unbalanced text. Too much emphasis on therapy, less on functional and molecular aspects. It should be extended considerably, by explaining the mechanism of HAE, and other potential activities unrelated of preoteinase inhibition.

- Error: it is told, that C1-inh is impossible to produce recombinantly. C1-inh was produced in mammalian, baculovirus, and yes, even in E. coli systems (although almost non-existent activity). Another highly effective system is yeast (Pichia pastoris).

- Highly irrelevant external links. Should be deleted or explained, and other links added.

- Only a single biased citation exists to credible information. This must be changed, to include original research papers presenting direct experimental work.

Maybe I will contribute in the near future.

Regards,

pl_denton

Last edited at 13:51, 4 May 2007 (UTC). Substituted at 10:38, 29 April 2016 (UTC)