Talk:Autophagy protein 5
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[edit] This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): Jwan225.
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Atg5 is E3 ligase?
[edit]Atg5 is the substrate of Atg12 and can form complex with Atg16. However, the E3 ligase of Atg5 is not defined as far as I know. Could anybody give citation of "Atg5 is ubiquitin E3 ligase"? — Preceding unsigned comment added by 137.222.52.183 (talk) 16:04, 24 November 2013 (UTC)
Here E3-like activitiy of Atg12-5 for Atg8 is described first: Hanada T, Noda NN, Satomi Y, Ichimura Y, Fujioka Y, Takao T, Inagaki F, Ohsumi Y. 2007. The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagy. J Biol Chem. 282(52). PMID: 23064152 --134.95.232.136 (talk) 12:33, 22 March 2019 (UTC)