Talk:Astemizole

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Ideal sources for Wikipedia's health content are defined in the guideline Wikipedia:Identifying reliable sources (medicine) and are typically review articles. Here are links to possibly useful sources of information about Astemizole.

PubMed provides review articles from the past five years (limit to free review articles)
The TRIP database provides clinical publications about evidence-based medicine.
Other potential sources include: Centre for Reviews and Dissemination and CDC

Cytochrome p450 3A4

My understanding is that Astemizole is a prodrug, which is expected to be metabolised into its active metabolite by first-pass hepatic metabolism; the prodrug is cardiotoxic, leading to an increased QTc on overdoes or when administered to a patient with impaired 3A4 activity. Unfortunately, I'm pulling this from a 10 year old text book, and the book prefaces its explanation of this with the statement that it hasn't been conclusively proven. Does anyone have a more up to date source, and if so, is this the correct explanation (I don't want to add misinformation, and I hate to use a book with a 1996 copyright as a source). --Badger151 04:18, 16 October 2006 (UTC)[reply]

Copyright problem

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