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The structure as drawn is: (3aS,12bS)-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole

and the stereochemistry is the reverse of what is written..is the structure wrong or the name???--ChemSpiderMan (talk) 00:48, 16 December 2007 (UTC)[reply]

Chem Abstracts has it as S,S (same as the image), so I changed the IUPAC name accordingly. -- Ed (Edgar181) 14:21, 18 December 2007 (UTC)[reply]
the drug is a racemate with fixed relative stereochemistry (source: PHARMACEUTICAL TECHNOLOGY 2012, Volume 36, Issue 3, pp. 58-72). Thus, the IUPAC name is correct, both the 2D and the 3D structures are wrong. In a moment these will be replaced by correct 2D structures of both enantiomers. Best regards, --Jü (talk) 05:31, 12 October 2013 (UTC)[reply]

Drug just approved by FDA I added some content from the package insert. I'm not sure the Ki and pKi values jive. They are from 2 different sources. I thought I know how to convert back and forth but it didn't seem to work. --Psychofarm (talk) 23:34, 5 September 2009 (UTC)[reply]

There's a sentence in the last paragraph of the introduction that is somewhat nonsensical. It reads as though its intent is to describe the means whereby Doctors use the drug to combat veterans (???) with severe PTSD. --24.102.148.14 (talk) 15:57, 3 August 2012 (UTC)[reply]

That's true if you treat "combat" in "combat veterans" as a verb and not an adjective - but to do that you would have to be intentionally misunderstanding the passage. NRPanikker (talk) 15:15, 22 May 2013 (UTC)[reply]

Saphrise

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I experience Fatigue, and Appetite, but is better than other drugs that made me gain 60lbs. I am afraid to try new drugs as I am still trying to lose weight. — Preceding unsigned comment added by 97.83.68.102 (talk) 21:42, 27 February 2016 (UTC)[reply]

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Schizophrenia use

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I fail to understand why this sentence is currently in this article, "There is only weak evidence supporting the use of Asenapine for treating schizophrenia, making it hard to recommend." The medication is FDA approved at least in the united states for the treatment of schizophrenia. The authority and author, "Ben Gray," says 1,800 subjects of 6 clinical trials provides poor quality for support that saphris is effective at treating schizophrenia because he judges the varsity of those studies, including possible bias from researches who are bound by the American Academy of Psychiatry and the law. I fail to see that source author's logic as well as the logic behind the statement in this article. If we are to believe everyone is too bias if not at all or enough neutral, then you might as well discredit all fda approved drugs. Ap4lmtree2 (talk) 06:45, 10 September 2019 (UTC)[reply]

History Correction

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I'm not familiar with this drug to comment on the history section, but this one appears to have been edited by a marijuana dispensary? The cited articles are definitely not appropriate. — Preceding unsigned comment added by 152.132.9.196 (talk) 19:42, 4 March 2020 (UTC)[reply]

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