Talk:Alkaline phosphatase

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This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): Nbazyan. Peer reviewers: Nbazyan.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 13:52, 16 January 2022 (UTC)

note

I've included some information on the research portion which says that mutant AK are usually used for research as their enzyme activity are higher.Nbazyan (talk) I'm going to include some introducing information for human physiology. I will include which isozymes in human serum predominate, and a fact of AK involving childhood.Nbazyan (talk) Furthermore, I'm going to edit the part on elevated alkaline phosphatase to include where exactly the alkaline phosphatase are coming from (referring to both skeletal and serum alkaline phosphatase) If anyone has any papers talking about the mechanisms, or which have more clarity on this, feel free to throw the name of the papers to me.Nbazyan (talk) —Preceding undated comment added 07:25, 1 May 2016 (UTC)

Could someone write a little more on separating the izoenzymes? Thanks. --Eleassar ^{my talk} 18:05, 12 September 2005 (UTC)

-- Could we mention that AlkPhos might be raised in polymalgia rheumatica? -- —Preceding unsigned comment added by 129.215.37.83 (talk) 12:42, 9 November 2007 (UTC)

Seconded. I just added something from the Oxford Textbook about heat stability, but I reckon there are now more sensitive ELISA or nephelometry-based modalities available. JFW | T@lk 19:50, 12 September 2005 (UTC)

My understanding of science is a world of pictures. Statement inferring the periplasmic space is adjacent to the outside of the cell is untrue and frustrating. Worse than wading through Guardian newspaper syntactic blunders! We should mean what we say and say what we mean at any level. — Preceding unsigned comment added by Dr.mike.buck (talk • contribs) 19:55, 6 April 2015 (UTC)

Figure

Will someone cite this figure? Also, it should have a PDB number.

Use in research

The change form 14:07, 9 December 2005 says - "Removing these phosphates prevents the DNA from ligating (the 5' end attaching to the 3' end of another molecule), thereby preventing DNA degradation until the next step of the process for which it is being prepared". Isn't an intramolecular ligation posible too? I think so, well, depending on how long these molecules are, right? If that's correct then we should revert this part to the original. Plz post a comment. Boris 13:57, 15 December 2005 (UTC)

Human: Diagnostic Use

It would be helpful if the article could indicate what level would be considered significantly elevated.

Also, does anyone have any paediatric values by either age or developmental stage - there is this idea that they are higher than adult values, but then how do we differentiate between raised Alk Phos from growth, and that from other pathologies such as low vitamin D (especially when we can't get the doctors to do Vitamin D tests)Kiwihelen (talk) 07:29, 15 August 2009 (UTC)

I came here to ask for the same thing .. normal levels please Dr B2 (talk) 14:09, 24 August 2011 (UTC)

The article still does not define "high" ALP. This is important. What is "high"? Association for Clinical Biochemistry and Laboratory Medicine (2013; http://www.acb.org.uk/docs/default-source/amalc/alp.pdf ) states normal departure from reference values are up to 3x in pregnancy, 2x in children. ALP may exceed five times the upper reference limit (5 x ULN) in cholestatic jaundice. Transiently elevated ALP (up to 10 x ULN) can occur as a benign condition in children and adults. — Preceding unsigned comment added by 67.0.70.56 (talk) 23:08, 3 March 2016 (UTC)

Levels of Alkaline Phosphatase

My Alkaline phosphatase is extremely high. Who could tell me why that is, and how our body recieves Alkaline phosphatase (i.e. what kind of food contains Alkaline phosphatase). How could I make it lower..Please help

ALP is a generally considered a marker of high bone activity - it is secreted by osteoblasts (bone forming cells). High ALP is often high in a high bone turnover state - i.e. when bone resorption is also high. This can be confirmed by other biochemical markers of bone resorption.

ALP is high in conditions such as Paget's disease of bone - a high bone turnover state that can lead to weakened and deformed bones, as well as bone pain.

These conditions are treated with drugs, such as bisphosphonates rather than diet. I suggest you consult your GP if you are concerned. Dr Aaron 04:40, 1 August 2006 (UTC)

I think the "normal" alkaline phosphatase levels should be adjusted or at least a disclaimer should be put that "normal" depends on the lab performing the test. Robbins/Goljan pathology go with 45-150 U/L as the normal range. As it is in the Wiki page, it's way too low as a "normal" range. Plus, it doesn't compensate for the fact that children have higher levels than adults. —Preceding unsigned comment added by Dirtyvu (talk • contribs) 05:03, 26 March 2008 (UTC)

Shouldn't the osteoblast activity be put into this article? 24.99.86.24 (talk) 20:15, 11 January 2009 (UTC)

Doesn't prostate cancer have high ACID phosphatase levels??? —Preceding unsigned comment added by 128.218.104.232 (talk) 22:54, 17 May 2009 (UTC)

Needs citation big time

None of the stuff on this page has citations, and none of the stuff is mentioned in the references or external links at the bottom of the page. Article needs to be flagged for this. —Preceding unsigned comment added by Farcanell (talk • contribs) 07:13, 11 October 2008 (UTC)

BSAP

This article needs a discussion of bone specific alkaline phosphatase (BSAP) which plays a role in, and is used as a marker of, bone formation.Struvite (talk) 00:45, 23 March 2012 (UTC)

Evaluating Tone of Article

The article is overall neutral. The article is mostly presenting information about the alkaline phosphatase enzyme and its relevance to research and science. There does not seem to be any claims that appear heavily biased towards a particular position. There also does not seem to be any viewpoints that are over represented or under represented in the article which seems to fit with the article topic since this is a science article detailing the information about the alkaline phosphatase enzyme Belunny23 (talk) 01:19, 2 April 2023 (UTC).

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