TRMU

TRMU
Identifiers
Aliases	TRMU, MTO2, MTU1, TRMT, TRMT1, TRNT1, LCAL3, tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase, tRNA mitochondrial 2-thiouridylase
External IDs	OMIM: 610230; MGI: 1919276; HomoloGene: 5589; GeneCards: TRMU; OMA:TRMU - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	46,357,340 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	85,781,595 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; right hemisphere of cerebellum; ; right uterine tube; ; anterior pituitary; ; right auricle; ; right lobe of thyroid gland; ; body of pancreas; ; ventricular zone; ; left ovary; ; right ovary;
	Top expressed in
	neural layer of retina; ; right kidney; ; interventricular septum; ; proximal tubule; ; otolith organ; ; neural tube; ; lens; ; utricle; ; ventricular zone; ; lumbar subsegment of spinal cord;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	RNA binding; transferase activity; tRNA binding; nucleotide binding; sulfurtransferase activity; ATP binding; methyltransferase activity;
Cellular component	mitochondrion; nucleoplasm;
Biological process	tRNA wobble position uridine thiolation; mitochondrial tRNA thio-modification; tRNA processing; methylation;
	Sources:Amigo / QuickGO
Orthologs
	55687
	72026
	ENSG00000100416
	ENSMUSG00000022386
	O75648; Q2PPL5
	Q9DAT5
NM_001008569; NM_001008571; NM_001282782; NM_001282783; NM_001282784;
	NM_001282785; NM_018006
	NM_028063
NP_001269711; NP_001269712; NP_001269713; NP_001269714; NP_060476;
	NP_001269711.1
	NP_082339
	Wikidata
View/Edit Human	View/Edit Mouse

Mitochondrial tRNA-specific 2-thiouridylase 1 is an enzyme that in humans is encoded by the TRMU gene.^[5]^[6]

This gene is a member of the trmU family. It encodes a mitochondria-specific tRNA-modifying enzyme that is required for the 2-thio modification of 5-taurinomethyl-2-thiouridine tRNA-Lys on the wobble position of the anticodon.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100416 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022386 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yan Q, Guan MX (Jan 2004). "Identification and characterization of mouse TRMU gene encoding the mitochondrial 5-methylaminomethyl-2-thiouridylate-methyltransferase". Biochim Biophys Acta. 1676 (2): 119–26. doi:10.1016/j.bbaexp.2003.11.010. PMID 14746906.
^ ^a ^b "Entrez Gene: TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase".

Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
Umeda N, Suzuki T, Yukawa M, et al. (2005). "Mitochondria-specific RNA-modifying enzymes responsible for the biosynthesis of the wobble base in mitochondrial tRNAs. Implications for the molecular pathogenesis of human mitochondrial diseases". J. Biol. Chem. 280 (2): 1613–24. doi:10.1074/jbc.M409306200. PMID 15509579.
Yan Q, Li X, Faye G, Guan MX (2005). "Mutations in MTO2 Related to tRNA Modification Impair Mitochondrial Gene Expression and Protein Synthesis in the Presence of a Paromomycin Resistance Mutation in Mitochondrial 15 S rRNA". J. Biol. Chem. 280 (32): 29151–7. doi:10.1074/jbc.M504247200. PMC 2905382. PMID 15944150.
Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.
Yan Q, Bykhovskaya Y, Li R, et al. (2006). "Human TRMU encoding the mitochondrial 5-methylaminomethyl-2-thiouridylate-methyltransferase is a putative nuclear modifier gene for the phenotypic expression of the deafness-associated 12S rRNA mutations". Biochem. Biophys. Res. Commun. 342 (4): 1130–6. doi:10.1016/j.bbrc.2006.02.078. PMID 16513084.
Guan MX, Yan Q, Li X, et al. (2006). "Mutation in TRMU Related to Transfer RNA Modification Modulates the Phenotypic Expression of the Deafness-Associated Mitochondrial 12S Ribosomal RNA Mutations". Am. J. Hum. Genet. 79 (2): 291–302. doi:10.1086/506389. PMC 1559489. PMID 16826519.

This article on a gene on human chromosome 22 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100416 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022386 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid14746906-5] Yan Q, Guan MX (Jan 2004). "Identification and characterization of mouse TRMU gene encoding the mitochondrial 5-methylaminomethyl-2-thiouridylate-methyltransferase". Biochim Biophys Acta. 1676 (2): 119–26. doi:10.1016/j.bbaexp.2003.11.010. PMID 14746906.

[entrez-6] "Entrez Gene: TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase".

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References

Further reading