TRIM55

TRIM55
Identifiers
Aliases	TRIM55, MURF-2, RNF29, muRF2, tripartite motif containing 55
External IDs	OMIM: 606469; MGI: 3036269; HomoloGene: 13205; GeneCards: TRIM55; OMA:TRIM55 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	66,175,485 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	19,746,585 bp
RNA expression pattern
	Top expressed in
	right auricle; ; myocardium of left ventricle; ; cardiac muscle tissue of right atrium; ; apex of heart; ; muscle of thigh; ; deltoid muscle; ; tibialis anterior muscle; ; right lobe of liver; ; gastrocnemius muscle; ; biceps brachii;
	Top expressed in
	heart; ; skeletal muscle tissue; ; quadriceps femoris muscle; ; muscle of thigh; ; esophagus; ; embryo; ; zone of skin; ; lip; ; lens; ; neural tube;
	More reference expression data
	n/a
Gene ontology
Molecular function	zinc ion binding; protein binding; signal transducer activity; metal ion binding; identical protein binding;
Cellular component	cytoplasm; microtubule; intracellular anatomical structure; nucleus;
Biological process	signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	84675
	381485
	ENSG00000147573
	ENSMUSG00000060913
	Q9BYV6
	G3X8Y1
	NM_033058; NM_184085; NM_184086; NM_184087
	NM_001081281
	NP_149047; NP_908973; NP_908974; NP_908975
	NP_001074750
	Wikidata
View/Edit Human	View/Edit Mouse

Tripartite motif-containing protein 55 is a protein that in humans is encoded by the TRIM55 gene.^[5]^[6]

The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein associates transiently with microtubules, myosin, and titin during muscle sarcomere assembly. It may act as a transient adaptor and plays a regulatory role in the assembly of sarcomeres. Four alternatively spliced transcript variants encoding distinct isoforms have been described.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000147573 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000060913 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Centner T, Yano J, Kimura E, McElhinny AS, Pelin K, Witt CC, Bang ML, Trombitas K, Granzier H, Gregorio CC, Sorimachi H, Labeit S (Mar 2001). "Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain". J Mol Biol. 306 (4): 717–26. doi:10.1006/jmbi.2001.4448. PMID 11243782.
^ ^a ^b "Entrez Gene: TRIM55 tripartite motif-containing 55".

McElhinny AS, Kakinuma K, Sorimachi H, et al. (2002). "Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1". J. Cell Biol. 157 (1): 125–36. doi:10.1083/jcb.200108089. PMC 2173255. PMID 11927605.
Pizon V, Iakovenko A, Van Der Ven PF, et al. (2003). "Transient association of titin and myosin with microtubules in nascent myofibrils directed by the MURF2 RING-finger protein". J. Cell Sci. 115 (Pt 23): 4469–82. doi:10.1242/jcs.00131. PMID 12414993. S2CID 16068484.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Kim J, Bhinge AA, Morgan XC, Iyer VR (2005). "Mapping DNA-protein interactions in large genomes by sequence tag analysis of genomic enrichment". Nat. Methods. 2 (1): 47–53. doi:10.1038/nmeth726. PMID 15782160. S2CID 6135437.
Lange S, Xiang F, Yakovenko A, et al. (2005). "The kinase domain of titin controls muscle gene expression and protein turnover". Science. 308 (5728): 1599–603. CiteSeerX 10.1.1.383.9888. doi:10.1126/science.1110463. PMID 15802564. S2CID 2809403.
Witt SH, Granzier H, Witt CC, Labeit S (2005). "MURF-1 and MURF-2 target a specific subset of myofibrillar proteins redundantly: towards understanding MURF-dependent muscle ubiquitination". J. Mol. Biol. 350 (4): 713–22. doi:10.1016/j.jmb.2005.05.021. PMID 15967462.

This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000147573 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000060913 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11243782-5] Centner T, Yano J, Kimura E, McElhinny AS, Pelin K, Witt CC, Bang ML, Trombitas K, Granzier H, Gregorio CC, Sorimachi H, Labeit S (Mar 2001). "Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain". J Mol Biol. 306 (4): 717–26. doi:10.1006/jmbi.2001.4448. PMID 11243782.

[entrez-6] "Entrez Gene: TRIM55 tripartite motif-containing 55".

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References

Further reading