TPD52L1

TPD52L1
Identifiers
Aliases	TPD52L1, D53, hD53, tumor protein D52-like 1, tumor protein D52 like 1, TPD52 like 1, TPD53
External IDs	OMIM: 604069; MGI: 1298386; HomoloGene: 2468; GeneCards: TPD52L1; OMA:TPD52L1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6q22.31 Start 125,119,049 bp End 125,264,407 bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10|10 A4 Start 31,208,372 bp End 31,321,954 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland right adrenal cortex germinal epithelium left adrenal gland left adrenal cortex putamen Epithelium of choroid plexus pancreatic ductal cell minor salivary glands external globus pallidus Top expressed in seminal vesicula parotid gland submandibular gland Epithelium of choroid plexus extraocular muscle dorsal striatum fourth ventricle choroid plexus of fourth ventricle lateral geniculate nucleus lateral septal nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein homodimerization activity identical protein binding protein heterodimerization activity Cellular component cytoplasm perinuclear region of cytoplasm Biological process positive regulation of apoptotic signaling pathway positive regulation of JNK cascade G2/M transition of mitotic cell cycle positive regulation of MAP kinase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7164 21987 Ensembl ENSG00000111907 ENSMUSG00000000296 UniProt Q16890 O54818 RefSeq (mRNA) NM_001003395 NM_001003396 NM_001003397 NM_001292026 NM_001300994 NM_003287 NM_001318903 NM_001318907 NM_009413 NM_001359364 NM_001359365 NM_001359366 RefSeq (protein) NP_001003395 NP_001003396 NP_001003397 NP_001278955 NP_001287923 NP_001305832 NP_001305836 NP_003278 NP_033439 NP_001346293 NP_001346294 NP_001346295 Location (UCSC) Chr 6: 125.12 – 125.26 Mb Chr 10: 31.21 – 31.32 Mb PubMed search
Wikidata
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Tumor protein D52 is a protein that in humans is encoded by the TPD52L1 gene.

Function

This gene encodes a member of the tumor protein D52 (TPD52) family. The encoded protein contains a coiled-coil domain and may form homo- or hetero-dimer with TPD52 family members. The protein is reported to be involved in cell proliferation and calcium signaling. It also interacts with the mitogen-activated protein kinase kinase kinase 5 (MAP3K5/ASK1) and positively regulates MAP3K5-induced apoptosis. Multiple alternatively spliced transcript variants have been observed, but the full-length nature of some variants has not yet been determined.

Interactions

TPD52L1 has been shown to interact with TPD52L2 and TPD52.

Further reading

• Byrne JA, Tomasetto C, Garnier JM, Rouyer N, Mattei MG, Bellocq JP, Rio MC, Basset P (1995). "A screening method to identify genes commonly overexpressed in carcinomas and the identification of a novel complementary DNA sequence". Cancer Res. 55 (13): 2896–2903. PMID 7796418.
• Byrne JA, Nourse CR, Basset P, Gunning P (1998). "Identification of homo- and heteromeric interactions between members of the breast carcinoma-associated D52 protein family using the yeast two-hybrid system". Oncogene. 16 (7): 873–881. doi:10.1038/sj.onc.1201604. PMID 9484778. S2CID 9948136.
• Byrne JA, Mattei MG, Basset P, Gunning P (1998). "Identification and in situ hybridization mapping of a mouse Tpd52l1 (D53) orthologue to chromosome 10A4-B2". Cytogenet. Cell Genet. 81 (3–4): 199–201. doi:10.1159/000015029. PMID 9730602. S2CID 46742110.
• Wilson SH, Bailey AM, Nourse CR, Mattei MG, Byrne JA (2001). "Identification of MAL2, a novel member of the mal proteolipid family, though interactions with TPD52-like proteins in the yeast two-hybrid system". Genomics. 76 (1–3): 81–88. doi:10.1006/geno.2001.6610. PMID 11549320.
• Sathasivam P, Bailey AM, Crossley M, Byrne JA (2001). "The role of the coiled-coil motif in interactions mediated by TPD52". Biochem. Biophys. Res. Commun. 288 (1): 56–61. doi:10.1006/bbrc.2001.5721. PMID 11594751.
• Boutros R, Bailey AM, Wilson SH, Byrne JA (2003). "Alternative splicing as a mechanism for regulating 14-3-3 binding: interactions between hD53 (TPD52L1) and 14-3-3 proteins". J. Mol. Biol. 332 (3): 675–687. doi:10.1016/S0022-2836(03)00944-6. PMID 12963375.
• Cho S, Ko HM, Kim JM, Lee JA, Park JE, Jang MS, Park SG, Lee DH, Ryu SE, Park BC (2004). "Positive regulation of apoptosis signal-regulating kinase 1 by hD53L1". J. Biol. Chem. 279 (16): 16050–16056. doi:10.1074/jbc.M305758200. PMID 14761963.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Barbaric D, Byth K, Dalla-Pozza L, Byrne JA (2006). "Expression of tumor protein D52-like genes in childhood leukemia at diagnosis: clinical and sample considerations". Leuk. Res. 30 (11): 1355–1363. doi:10.1016/j.leukres.2006.03.009. PMID 16620967.
• Cao Q, Chen J, Zhu L, Liu Y, Zhou Z, Sha J, Wang S, Li J (2006). "A testis-specific and testis developmentally regulated tumor protein D52 (TPD52)-like protein TPD52L3/hD55 interacts with TPD52 family proteins". Biochem. Biophys. Res. Commun. 344 (3): 798–806. doi:10.1016/j.bbrc.2006.03.208. PMID 16631610.