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TNIK

From Wikipedia, the free encyclopedia
TNIK
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTNIK, TRAF2 and NCK interacting kinase, MRT54
External IDsOMIM: 610005; MGI: 1916264; HomoloGene: 77943; GeneCards: TNIK; OMA:TNIK - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001163007
NM_001163008
NM_001163009
NM_026910

RefSeq (protein)

NP_001156479
NP_001156480
NP_001156481
NP_081186

Location (UCSC)Chr 3: 171.06 – 171.46 MbChr 3: 28.32 – 28.73 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

TRAF2 and NCK-interacting protein kinase is an enzyme that in humans is encoded by the TNIK gene.[5][6][7] TNIK is involved in various cellular processes, including signal transduction, gene transcription, and cytoskeletal organization. As an emerging area of therapeutic research, TNIK inhibitors have shown potential in addressing a range of diseases, including cancer, neurological disorders, and inflammatory conditions.[8][9][10]

Function

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Germinal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function.[6][7]

Interactions

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TNIK has been shown to interact with KIAA0090,[11] although the significance is unclear. TNIK has been shown to phosphorylate Gelsolin, a protein involved in F-actin depolymerisation thus inducing cytoskeletal changes.[6]

TNIK plays an important role in pulmonary fibrosis. TNIK inhibitors are used in the treatment of pulmonary fibrosis.[9]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000154310Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027692Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Aug 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.
  6. ^ a b c Fu CA, Shen M, Huang BC, Lasaga J, Payan DG, Luo Y (Nov 1999). "TNIK, a novel member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and regulates the cytoskeleton". J Biol Chem. 274 (43): 30729–37. doi:10.1074/jbc.274.43.30729. PMID 10521462.
  7. ^ a b "Entrez Gene: TNIK TRAF2 and NCK interacting kinase".
  8. ^ Yamada, Tesshi; Masuda, Mari (May 2017). "Emergence of TNIK inhibitors in cancer therapeutics". Cancer Sci. 108 (5): 818–823. doi:10.1111/cas.13203. PMC 5448614. PMID 28208209.
  9. ^ a b Garneau-Tsodikova, Sylvie; Thannickal, Victor J. (2008). "Protein kinase inhibitors in the treatment of pulmonary fibrosis". Current Medicinal Chemistry. 15 (25): 2632–2640. doi:10.2174/092986708785908969. ISSN 0929-8673. PMID 18855683.
  10. ^ Ewald, Collin Y.; Pulous, Fadi E.; Lok, Sarah Wing Yan; Pun, Frank W.; Aliper, Alex; Ren, Feng; Zhavoronkov, Alex (June 2024). "TNIK's emerging role in cancer, metabolism, and age-related diseases". Trends in Pharmacological Sciences. 45 (6): 478–489. doi:10.1016/j.tips.2024.04.010. hdl:20.500.11850/677315. PMID 38777670.
  11. ^ Prieto C, De Las Rivas J (July 2006). "APID: Agile Protein Interaction DataAnalyzer". Nucleic Acids Res. 34 (Web Server issue): W298–302. doi:10.1093/nar/gkl128. PMC 1538863. PMID 16845013. Archived from the original on 2010-04-09.

Further reading

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