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Protein-coding gene in the species Homo sapiens
Protein-glutamine gamma-glutamyltransferase E is an enzyme that in humans is encoded by the TGM3 gene .[ 5] [ 6] [ 7]
Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene consists of two polypeptide chains activated from a single precursor protein by proteolysis. The encoded protein is involved the later stages of cell envelope formation in the epidermis and hair follicle.[ 7]
^ a b c GRCh38: Ensembl release 89: ENSG00000125780 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027401 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Wang M, Kim IG, Steinert PM, McBride OW (Mar 1995). "Assignment of the human transglutaminase 2 (TGM2) and transglutaminase 3 (TGM3) genes to chromosome 20q11.2" . Genomics . 23 (3): 721–2. doi :10.1006/geno.1994.1571 . PMID 7851911 . ^ Aeschlimann D, Koeller MK, Allen-Hoffmann BL, Mosher DF (Mar 1998). "Isolation of a cDNA encoding a novel member of the transglutaminase gene family from human keratinocytes. Detection and identification of transglutaminase gene products based on reverse transcription-polymerase chain reaction with degenerate primers" . J Biol Chem . 273 (6): 3452–60. doi :10.1074/jbc.273.6.3452 PMID 9452468 . ^ a b "Entrez Gene: TGM3 transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)" .
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PDB gallery
1l9m : Three-dimensional structure of the human transglutaminase 3 enzyme: binding of calcium ions change structure for activation
1l9n : Three-dimensional structure of the human transglutaminase 3 enzyme: binding of calcium ions change structure for activation
1nud : Role of Calcium Ions in the Activation and Activity of the Transglutaminase 3 Enzyme (3 calciums, active form)
1nuf : Role of Calcium Ions in the Activation and Activity of the Transglutaminase 3 Enzyme
1nug : Role of Calcium Ions in the Activation and Activity of the Transglutaminase 3 Enzyme (2 calciums, 1 Mg, inactive form)
1rle : Structural Basis for the Coordinated Regulation of Transglutaminase 3 by Guanine Nucleotides and Calcium/Magnesium
1sgx : Crystal Structure of Transglutaminase 3 in Complex with Bound GMP: Structural Basis for Alteration in Nucleotide Specificity
1vjj : Structural Basis for the Coordinated Regulation of Transglutaminase 3 by Guanine Nucleotides and Calcium/Magnesium
