TFCP2

TFCP2
Identifiers
Aliases	TFCP2, LBP1C, LSF, LSF1D, SEF, TFCP2C, transcription factor CP2
External IDs	OMIM: 189889; MGI: 98509; HomoloGene: 4134; GeneCards: TFCP2; OMA:TFCP2 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	51,173,135 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	100,449,889 bp
RNA expression pattern
	Top expressed in
	mucosa of paranasal sinus; ; superficial temporal artery; ; ventricular zone; ; monocyte; ; ganglionic eminence; ; granulocyte; ; rectum; ; gastrocnemius muscle; ; gonad; ; islet of Langerhans;
	Top expressed in
	neural layer of retina; ; pineal gland; ; genital tubercle; ; tail of embryo; ; ventricular zone; ; perirhinal cortex; ; renal corpuscle; ; entorhinal cortex; ; right kidney; ; neural tube;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; DNA binding; protein C-terminus binding; protein binding; sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; cis-regulatory region sequence-specific DNA binding; transcription factor binding; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding;
Cellular component	nucleoplasm; cytosol; nucleus; protein-containing complex;
Biological process	regulation of transcription, DNA-templated; transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; mRNA transcription by RNA polymerase II; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	7024
	21422
	ENSG00000135457
	ENSMUSG00000009733
	Q12800
	Q9ERA0
	NM_005653; NM_001173452; NM_001173453
	NM_001289603; NM_033476; NM_001355497
	NP_001166923; NP_001166924; NP_005644
	NP_001276532; NP_258437; NP_001342426
	Wikidata
View/Edit Human	View/Edit Mouse

Alpha-globin transcription factor CP2 is a protein that in humans is encoded by the TFCP2 gene.^[5]^[6]

TFCP2 is also called Late SV40 factor (LSF) and it is induced by well-known oncogene AEG-1.^[7] LSF also acts as an oncogene in hepatocellular carcinoma.^[8] LSF enhances angiogenesis by transcriptionally up-regulating matrix metalloproteinase-9 (MMP9).^[9]

Along with its main oncogene function in hepatocellular carcinoma (HCC), it plays multifaceted role in chemoresistance, epithelial-mesenchymal transition (EMT), allergic response, inflammation and Alzheimer's disease.^[8]^[10] The small molecule FQI1 (factor quinolinone inhibitor 1) prevents LSF from binding with HCC DNA, which results in HCC cell death.^[8]^[10]^[11]

Interactions

TFCP2 has been shown to interact with APBB1^[12] and RNF2.^[13]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000135457 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000009733 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Swendeman SL, Spielholz C, Jenkins NA, Gilbert DJ, Copeland NG, Sheffery M (Apr 1994). "Characterization of the genomic structure, chromosomal location, promoter, and development expression of the alpha-globin transcription factor CP2". The Journal of Biological Chemistry. 269 (15): 11663–71. doi:10.1016/S0021-9258(19)78176-9. PMID 8157699.
^ "Entrez Gene: TFCP2 transcription factor CP2".
^ Yoo BK, Gredler R, Vozhilla N, Su ZZ, Chen D, Forcier T, Shah K, Saxena U, Hansen U, Fisher PB, Sarkar D (Aug 2009). "Identification of genes conferring resistance to 5-fluorouracil". Proceedings of the National Academy of Sciences of the United States of America. 106 (31): 12938–43. Bibcode:2009PNAS..10612938Y. doi:10.1073/pnas.0901451106. PMC 2722317. PMID 19622726.
^ ^a ^b ^c Yoo BK, Emdad L, Gredler R, Fuller C, Dumur CI, Jones KH, Jackson-Cook C, Su ZZ, Chen D, Saxena UH, Hansen U, Fisher PB, Sarkar D (May 2010). "Transcription factor Late SV40 Factor (LSF) functions as an oncogene in hepatocellular carcinoma". Proceedings of the National Academy of Sciences of the United States of America. 107 (18): 8357–62. Bibcode:2010PNAS..107.8357Y. doi:10.1073/pnas.1000374107. PMC 2889542. PMID 20404171.
^ Santhekadur PK, Gredler R, Chen D, Siddiq A, Shen XN, Das SK, Emdad L, Fisher PB, Sarkar D (Jan 2012). "Late SV40 factor (LSF) enhances angiogenesis by transcriptionally up-regulating matrix metalloproteinase-9 (MMP-9)". The Journal of Biological Chemistry. 287 (5): 3425–32. doi:10.1074/jbc.M111.298976. PMC 3270996. PMID 22167195.
^ ^a ^b Santhekadur PK, Rajasekaran D, Siddiq A, Gredler R, Chen D, Schaus SC, Hansen U, Fisher PB, Sarkar D (2012). "The transcription factor LSF: a novel oncogene for hepatocellular carcinoma" (PDF). Am J Cancer Res. 2 (3): 269–285. PMC 3365805. PMID 22679558.
^ Grant TJ, Bishop JA, Christadore LM, Barot G, Chin HG, Woodson S, Kavouris J, Siddiq A, Gredler R, Shen XN, Sherman J, Meehan T, Fitzgerald K, Pradhan S, Briggs LA, Andrews WH, Sarkar D, Schaus SE, Hansen U (Mar 2012). "Antiproliferative small-molecule inhibitors of transcription factor LSF reveal oncogene addiction to LSF in hepatocellular carcinoma". Proceedings of the National Academy of Sciences of the United States of America. 109 (12): 4503–8. Bibcode:2012PNAS..109.4503G. doi:10.1073/pnas.1121601109. PMC 3311344. PMID 22396589.
^ Zambrano N, Minopoli G, de Candia P, Russo T (Aug 1998). "The Fe65 adaptor protein interacts through its PID1 domain with the transcription factor CP2/LSF/LBP1". The Journal of Biological Chemistry. 273 (32): 20128–33. doi:10.1074/jbc.273.32.20128. PMID 9685356.
^ Tuckfield A, Clouston DR, Wilanowski TM, Zhao LL, Cunningham JM, Jane SM (Mar 2002). "Binding of the RING polycomb proteins to specific target genes in complex with the grainyhead-like family of developmental transcription factors". Molecular and Cellular Biology. 22 (6): 1936–46. doi:10.1128/MCB.22.6.1936-1946.2002. PMC 135618. PMID 11865070.

Lim LC, Swendeman SL, Sheffery M (Feb 1992). "Molecular cloning of the alpha-globin transcription factor CP2". Molecular and Cellular Biology. 12 (2): 828–35. doi:10.1128/mcb.12.2.828. PMC 364316. PMID 1732747.
Jane SM, Nienhuis AW, Cunningham JM (Jan 1995). "Hemoglobin switching in man and chicken is mediated by a heteromeric complex between the ubiquitous transcription factor CP2 and a developmentally specific protein". The EMBO Journal. 14 (1): 97–105. doi:10.1002/j.1460-2075.1995.tb06979.x. PMC 398056. PMID 7828600.
Shirra MK, Zhu Q, Huang HC, Pallas D, Hansen U (Aug 1994). "One exon of the human LSF gene includes conserved regions involved in novel DNA-binding and dimerization motifs". Molecular and Cellular Biology. 14 (8): 5076–87. doi:10.1128/mcb.14.8.5076. PMC 359026. PMID 8035790.
Yoon JB, Li G, Roeder RG (Mar 1994). "Characterization of a family of related cellular transcription factors which can modulate human immunodeficiency virus type 1 transcription in vitro". Molecular and Cellular Biology. 14 (3): 1776–85. doi:10.1128/mcb.14.3.1776. PMC 358535. PMID 8114710.
Margolis DM, Somasundaran M, Green MR (Feb 1994). "Human transcription factor YY1 represses human immunodeficiency virus type 1 transcription and virion production". Journal of Virology. 68 (2): 905–10. doi:10.1128/JVI.68.2.905-910.1994. PMC 236527. PMID 8289393.
Cunningham JM, Vanin EF, Tran N, Valentine M, Jane SM (Nov 1995). "The human transcription factor CP2 (TFCP2), a component of the human gamma-globin stage selector protein, maps to chromosome region 12q13 and is within 250 kb of the NF-E2 gene". Genomics. 30 (2): 398–9. PMID 8586452.
Romerio F, Gabriel MN, Margolis DM (Dec 1997). "Repression of human immunodeficiency virus type 1 through the novel cooperation of human factors YY1 and LSF". Journal of Virology. 71 (12): 9375–82. doi:10.1128/JVI.71.12.9375-9382.1997. PMC 230241. PMID 9371597.
Zambrano N, Minopoli G, de Candia P, Russo T (Aug 1998). "The Fe65 adaptor protein interacts through its PID1 domain with the transcription factor CP2/LSF/LBP1". The Journal of Biological Chemistry. 273 (32): 20128–33. doi:10.1074/jbc.273.32.20128. PMID 9685356.
Bing Z, Reddy SA, Ren Y, Qin J, Liao WS (Aug 1999). "Purification and characterization of the serum amyloid A3 enhancer factor". The Journal of Biological Chemistry. 274 (35): 24649–56. doi:10.1074/jbc.274.35.24649. PMID 10455131.
Coull JJ, Romerio F, Sun JM, Volker JL, Galvin KM, Davie JR, Shi Y, Hansen U, Margolis DM (Aug 2000). "The human factors YY1 and LSF repress the human immunodeficiency virus type 1 long terminal repeat via recruitment of histone deacetylase 1". Journal of Virology. 74 (15): 6790–9. doi:10.1128/JVI.74.15.6790-6799.2000. PMC 112196. PMID 10888618.
Zhou W, Clouston DR, Wang X, Cerruti L, Cunningham JM, Jane SM (Oct 2000). "Induction of human fetal globin gene expression by a novel erythroid factor, NF-E4". Molecular and Cellular Biology. 20 (20): 7662–72. doi:10.1128/MCB.20.20.7662-7672.2000. PMC 86334. PMID 11003662.
Rodda S, Sharma S, Scherer M, Chapman G, Rathjen P (Feb 2001). "CRTR-1, a developmentally regulated transcriptional repressor related to the CP2 family of transcription factors". The Journal of Biological Chemistry. 276 (5): 3324–32. doi:10.1074/jbc.M008167200. PMID 11073954.
Zheng JB, Zhou YH, Maity T, Liao WS, Saunders GF (Oct 2001). "Activation of the human PAX6 gene through the exon 1 enhancer by transcription factors SEF and Sp1". Nucleic Acids Research. 29 (19): 4070–8. doi:10.1093/nar/29.2.e6. PMC 60230. PMID 11574690.
Tuckfield A, Clouston DR, Wilanowski TM, Zhao LL, Cunningham JM, Jane SM (Mar 2002). "Binding of the RING polycomb proteins to specific target genes in complex with the grainyhead-like family of developmental transcription factors". Molecular and Cellular Biology. 22 (6): 1936–46. doi:10.1128/MCB.22.6.1936-1946.2002. PMC 135618. PMID 11865070.
He G, Margolis DM (May 2002). "Counterregulation of chromatin deacetylation and histone deacetylase occupancy at the integrated promoter of human immunodeficiency virus type 1 (HIV-1) by the HIV-1 repressor YY1 and HIV-1 activator Tat". Molecular and Cellular Biology. 22 (9): 2965–73. doi:10.1128/MCB.22.9.2965-2973.2002. PMC 133763. PMID 11940654.
Peters LM, Anderson DW, Griffith AJ, Grundfast KM, San Agustin TB, Madeo AC, Friedman TB, Morell RJ (Nov 2002). "Mutation of a transcription factor, TFCP2L3, causes progressive autosomal dominant hearing loss, DFNA28". Human Molecular Genetics. 11 (23): 2877–85. doi:10.1093/hmg/11.23.2877. PMID 12393799.
Luedecking-Zimmer E, DeKosky ST, Nebes R, Kamboh MI (Feb 2003). "Association of the 3' UTR transcription factor LBP-1c/CP2/LSF polymorphism with late-onset Alzheimer's disease". American Journal of Medical Genetics Part B. 117B (1): 114–7. doi:10.1002/ajmg.b.10026. PMID 12555245. S2CID 24087609.
Chae JH, Kim CG (Feb 2003). "CP2 binding to the promoter is essential for the enhanced transcription of globin genes in erythroid cells". Molecules and Cells. 15 (1): 40–7. doi:10.1016/S1016-8478(23)25235-8. PMID 12661759.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000135457 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000009733 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8157699-5] Swendeman SL, Spielholz C, Jenkins NA, Gilbert DJ, Copeland NG, Sheffery M (Apr 1994). "Characterization of the genomic structure, chromosomal location, promoter, and development expression of the alpha-globin transcription factor CP2". The Journal of Biological Chemistry. 269 (15): 11663–71. doi:10.1016/S0021-9258(19)78176-9. PMID 8157699.

[entrez-6] "Entrez Gene: TFCP2 transcription factor CP2".

[pmid19622726-7] Yoo BK, Gredler R, Vozhilla N, Su ZZ, Chen D, Forcier T, Shah K, Saxena U, Hansen U, Fisher PB, Sarkar D (Aug 2009). "Identification of genes conferring resistance to 5-fluorouracil". Proceedings of the National Academy of Sciences of the United States of America. 106 (31): 12938–43. Bibcode:2009PNAS..10612938Y. doi:10.1073/pnas.0901451106. PMC 2722317. PMID 19622726.

[pmid20404171-8] Yoo BK, Emdad L, Gredler R, Fuller C, Dumur CI, Jones KH, Jackson-Cook C, Su ZZ, Chen D, Saxena UH, Hansen U, Fisher PB, Sarkar D (May 2010). "Transcription factor Late SV40 Factor (LSF) functions as an oncogene in hepatocellular carcinoma". Proceedings of the National Academy of Sciences of the United States of America. 107 (18): 8357–62. Bibcode:2010PNAS..107.8357Y. doi:10.1073/pnas.1000374107. PMC 2889542. PMID 20404171.

[pmid22167195-9] Santhekadur PK, Gredler R, Chen D, Siddiq A, Shen XN, Das SK, Emdad L, Fisher PB, Sarkar D (Jan 2012). "Late SV40 factor (LSF) enhances angiogenesis by transcriptionally up-regulating matrix metalloproteinase-9 (MMP-9)". The Journal of Biological Chemistry. 287 (5): 3425–32. doi:10.1074/jbc.M111.298976. PMC 3270996. PMID 22167195.

[Santhekadur-10] Santhekadur PK, Rajasekaran D, Siddiq A, Gredler R, Chen D, Schaus SC, Hansen U, Fisher PB, Sarkar D (2012). "The transcription factor LSF: a novel oncogene for hepatocellular carcinoma" (PDF). Am J Cancer Res. 2 (3): 269–285. PMC 3365805. PMID 22679558.

[pmid22396589-11] Grant TJ, Bishop JA, Christadore LM, Barot G, Chin HG, Woodson S, Kavouris J, Siddiq A, Gredler R, Shen XN, Sherman J, Meehan T, Fitzgerald K, Pradhan S, Briggs LA, Andrews WH, Sarkar D, Schaus SE, Hansen U (Mar 2012). "Antiproliferative small-molecule inhibitors of transcription factor LSF reveal oncogene addiction to LSF in hepatocellular carcinoma". Proceedings of the National Academy of Sciences of the United States of America. 109 (12): 4503–8. Bibcode:2012PNAS..109.4503G. doi:10.1073/pnas.1121601109. PMC 3311344. PMID 22396589.

[pmid9685356-12] Zambrano N, Minopoli G, de Candia P, Russo T (Aug 1998). "The Fe65 adaptor protein interacts through its PID1 domain with the transcription factor CP2/LSF/LBP1". The Journal of Biological Chemistry. 273 (32): 20128–33. doi:10.1074/jbc.273.32.20128. PMID 9685356.

[pmid11865070-13] Tuckfield A, Clouston DR, Wilanowski TM, Zhao LL, Cunningham JM, Jane SM (Mar 2002). "Binding of the RING polycomb proteins to specific target genes in complex with the grainyhead-like family of developmental transcription factors". Molecular and Cellular Biology. 22 (6): 1936–46. doi:10.1128/MCB.22.6.1936-1946.2002. PMC 135618. PMID 11865070.

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Interactions

References

Further reading