TCEAL1

TCEAL1
Identifiers
Aliases	TCEAL1, SIIR, WEX9, p21, pp21, transcription elongation factor A like 1
External IDs	OMIM: 300237; MGI: 2385317; HomoloGene: 3510; GeneCards: TCEAL1; OMA:TCEAL1 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	103,630,953 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	135,612,227 bp
RNA expression pattern
	Top expressed in
	right ovary; ; left ovary; ; left uterine tube; ; body of uterus; ; gastric mucosa; ; right coronary artery; ; canal of the cervix; ; thoracic aorta; ; Descending thoracic aorta; ; ascending aorta;
	Top expressed in
	dorsomedial hypothalamic nucleus; ; facial motor nucleus; ; mammillary body; ; arcuate nucleus; ; paraventricular nucleus of hypothalamus; ; median eminence; ; ventromedial nucleus; ; Region I of hippocampus proper; ; barrel cortex; ; lateral hypothalamus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; WW domain binding;
Cellular component	nucleus; nucleoplasm;
Biological process	regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologs
	9338
	237052
	ENSG00000172465
	ENSMUSG00000049536
	Q15170
	Q921P9
	NM_004780; NM_001006639; NM_001006640
	NM_146236; NM_001356367
	NP_001006640; NP_001006641; NP_004771
	NP_666348; NP_001343296
	Wikidata
View/Edit Human	View/Edit Mouse

Transcription elongation factor A protein-like 1 is a protein that in humans is encoded by the TCEAL1 gene.^[5]^[6]^[7]

This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of this family may function as nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. The encoded protein is similar to transcription elongation factor A/transcription factor SII and contains a zinc finger-like motif as well as a sequence related to the transcription factor SII Pol II-binding region. It may exert its effects via protein-protein interactions with other transcriptional regulators rather than via direct binding of DNA. Multiple family members are located on the X chromosome. Alternative splicing results in multiple transcript variants encoding a single isoform.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000172465 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000049536 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yeh CH, Shatkin AJ (Jul 1994). "A HeLa-cell-encoded p21 is homologous to transcription elongation factor SII". Gene. 143 (2): 285–7. doi:10.1016/0378-1119(94)90112-0. PMID 8206389.
^ Yeh CH, Shatkin AJ (Dec 1994). "Down-regulation of Rous sarcoma virus long terminal repeat promoter activity by a HeLa cell basic protein". Proc Natl Acad Sci U S A. 91 (23): 11002–6. Bibcode:1994PNAS...9111002Y. doi:10.1073/pnas.91.23.11002. PMC 45154. PMID 7971997.
^ ^a ^b "Entrez Gene: TCEAL1 transcription elongation factor A (SII)-like 1".

Yeh CH, Zong WX, Shatkin AJ (1995). "The Ser36-Ser37 pair in HeLa nuclear protein p21/SIIR mediates Ser/Thr phosphorylation and is essential for Rous sarcoma virus long terminal repeat repression". J. Biol. Chem. 270 (43): 25313–5. doi:10.1074/jbc.270.44.26558. PMID 7592688.
Pillutla RC, Shimamoto A, Furuichi Y, Shatkin AJ (1999). "Genomic structure and chromosomal localization of TCEAL1, a human gene encoding the nuclear phosphoprotein p21/SIIR". Genomics. 56 (2): 217–20. doi:10.1006/geno.1998.5705. PMID 10051408.
van der Kuip H, Carius B, Haque SJ, et al. (1999). "The DNA-binding subunit p140 of replication factor C is upregulated in cycling cells and associates with G1 phase cell cycle regulatory proteins". J. Mol. Med. 77 (4): 386–92. doi:10.1007/s001090050365. PMID 10353443. S2CID 22183443.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
Makino H, Tajiri T, Miyashita M, et al. (2005). "Differential expression of TCEAL1 in esophageal cancers by custom cDNA microarray analysis". Diseases of the Esophagus. 18 (1): 37–40. doi:10.1111/j.1442-2050.2005.00432.x. PMID 15773840.
Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000172465 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000049536 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8206389-5] Yeh CH, Shatkin AJ (Jul 1994). "A HeLa-cell-encoded p21 is homologous to transcription elongation factor SII". Gene. 143 (2): 285–7. doi:10.1016/0378-1119(94)90112-0. PMID 8206389.

[pmid7971997-6] Yeh CH, Shatkin AJ (Dec 1994). "Down-regulation of Rous sarcoma virus long terminal repeat promoter activity by a HeLa cell basic protein". Proc Natl Acad Sci U S A. 91 (23): 11002–6. Bibcode:1994PNAS...9111002Y. doi:10.1073/pnas.91.23.11002. PMC 45154. PMID 7971997.

[entrez-7] "Entrez Gene: TCEAL1 transcription elongation factor A (SII)-like 1".

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References

Further reading