TCEA2

TCEA2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2LW4
Identifiers
Aliases	TCEA2, TFIIS, transcription elongation factor A2
External IDs	OMIM: 604784; MGI: 107368; HomoloGene: 68304; GeneCards: TCEA2; OMA:TCEA2 - orthologs
Gene location (Human) Chr. Chromosome 20 (human) Band 20q13.33 Start 64,049,836 bp End 64,072,347 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2 H4|2 103.72 cM Start 181,322,103 bp End 181,329,864 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum right frontal lobe left testis right testis nucleus accumbens prefrontal cortex cingulate gyrus anterior cingulate cortex anterior pituitary ventricular zone Top expressed in spermatocyte spermatid seminiferous tubule superior frontal gyrus primary visual cortex dentate gyrus of hippocampal formation granule cell facial motor nucleus cerebellar cortex granulocyte anterior horn of spinal cord More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding zinc ion binding protein binding metal ion binding nucleic acid binding translation elongation factor activity Cellular component transcription elongation factor complex nucleus Biological process DNA-templated transcription, elongation regulation of transcription, DNA-templated transcription, DNA-templated positive regulation of transcription by RNA polymerase II regulation of DNA-templated transcription, elongation translational elongation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6919 21400 Ensembl ENSG00000171703 ENSMUSG00000059540 UniProt Q15560 Q6IB64 Q9QVN7 RefSeq (mRNA) NM_003195 NM_198723 NM_009326 NM_001356342 NM_001356343 RefSeq (protein) NP_003186 NP_942016 NP_003186.1 NP_033352 NP_001343271 NP_001343272 Location (UCSC) Chr 20: 64.05 – 64.07 Mb Chr 2: 181.32 – 181.33 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Transcription elongation factor A protein 2 is a protein that in humans is encoded by the TCEA2 gene.

Function

The protein encoded by this gene is found in the nucleus, where it functions as an SII class transcription elongation factor. Elongation factors in this class are responsible for releasing RNA polymerase II ternary complexes from transcriptional arrest at template-encoded arresting sites. The encoded protein has been shown to interact with general transcription factor IIB, a basal transcription factor. Two transcript variants encoding different isoforms have been found for this gene.

Interactions

TCEA2 has been shown to interact with MAGEA11.

Further reading

• Kato H, Sumimoto H, Pognonec P, Chen CH, Rosen CA, Roeder RG (Apr 1992). "HIV-1 Tat acts as a processivity factor in vitro in conjunction with cellular elongation factors". Genes & Development. 6 (4): 655–66. doi:10.1101/gad.6.4.655. PMID 1559613.
• Li XY, Green MR (Oct 1998). "The HIV-1 Tat cellular coactivator Tat-SF1 is a general transcription elongation factor". Genes & Development. 12 (19): 2992–6. doi:10.1101/gad.12.19.2992. PMC 317190. PMID 9765201.
• Trembley JH, Hu D, Hsu LC, Yeung CY, Slaughter C, Lahti JM, Kidd VJ (Jan 2002). "PITSLRE p110 protein kinases associate with transcription complexes and affect their activity". The Journal of Biological Chemistry. 277 (4): 2589–96. doi:10.1074/jbc.M109755200. PMID 11709559.
• Sijbrandi R, Fiedler U, Timmers HT (Jun 2002). "RNA polymerase II complexes in the very early phase of transcription are not susceptible to TFIIS-induced exonucleolytic cleavage". Nucleic Acids Research. 30 (11): 2290–8. doi:10.1093/nar/30.11.2290. PMC 117193. PMID 12034815.
• Saso K, Ito T, Natori S, Sekimizu K (Apr 2003). "Identification of a novel tissue-specific transcriptional activator FESTA as a protein that interacts with the transcription elongation factor S-II". Journal of Biochemistry. 133 (4): 493–500. doi:10.1093/jb/mvg065. PMID 12761297.
• Tamura K, Miyata K, Sugahara K, Onishi S, Shuin T, Aso T (Sep 2003). "Identification of EloA-BP1, a novel Elongin A binding protein with an exonuclease homology domain". Biochemical and Biophysical Research Communications. 309 (1): 189–95. doi:10.1016/S0006-291X(03)01556-0. PMID 12943681.
• Nakata A, Ito T, Nagata M, Hori S, Sekimizu K (Nov 2004). "GRIP1tau, a novel PDZ domain-containing transcriptional activator, cooperates with the testis-specific transcription elongation factor SII-T1". Genes to Cells. 9 (11): 1125–35. doi:10.1111/j.1365-2443.2004.00795.x. PMID 15507123. S2CID 23334030.
• Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Palangat M, Renner DB, Price DH, Landick R (Oct 2005). "A negative elongation factor for human RNA polymerase II inhibits the anti-arrest transcript-cleavage factor TFIIS". Proceedings of the National Academy of Sciences of the United States of America. 102 (42): 15036–41. Bibcode:2005PNAS..10215036P. doi:10.1073/pnas.0409405102. PMC 1257689. PMID 16214896.
• Kuraoka I, Suzuki K, Ito S, Hayashida M, Kwei JS, Ikegami T, Handa H, Nakabeppu Y, Tanaka K (Jun 2007). "RNA polymerase II bypasses 8-oxoguanine in the presence of transcription elongation factor TFIIS". DNA Repair. 6 (6): 841–51. doi:10.1016/j.dnarep.2007.01.014. PMID 17374514.