Syntaphilin

SNPH
Identifiers
Aliases	SNPH, bA314N13.5, syntaphilin
External IDs	OMIM: 604942; MGI: 2139270; HomoloGene: 8817; GeneCards: SNPH; OMA:SNPH - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	1,309,328 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	151,632,593 bp
RNA expression pattern
	Top expressed in
	Region I of hippocampus proper; ; Brodmann area 46; ; postcentral gyrus; ; orbitofrontal cortex; ; entorhinal cortex; ; superior frontal gyrus; ; dorsal motor nucleus of vagus nerve; ; right frontal lobe; ; inferior olivary nucleus; ; cingulate gyrus;
	Top expressed in
	visual cortex; ; primary visual cortex; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; subiculum; ; hippocampus proper; ; prefrontal cortex; ; cingulate gyrus; ; olfactory tubercle; ; primary motor cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	syntaxin-1 binding;
Cellular component	cytoplasm; integral component of membrane; neuron projection; cytoplasmic microtubule; cell junction; soma; plasma membrane; synapse; presynaptic membrane; mitochondrial membranes; membrane;
Biological process	brain development; synaptic vesicle docking; neurotransmitter secretion; neuron differentiation;
	Sources:Amigo / QuickGO
Orthologs
	9751
	241727
	ENSG00000101298
	ENSMUSG00000027457
	O15079
	Q80U23
	NM_014723; NM_001318234
	NM_001291076; NM_001291077; NM_198214
	NP_001305163; NP_055538
	NP_001278005; NP_001278006; NP_937857
	Wikidata
View/Edit Human	View/Edit Mouse

Syntaphilin is a protein that in humans is encoded by the SNPH gene. ^[5]

Function

Syntaxin-1, synaptobrevin/VAMP, and SNAP25 interact to form the SNARE complex, which is required for synaptic vesicle docking and fusion. The protein encoded by this gene is membrane-associated and inhibits SNARE complex formation by binding free syntaxin-1. Expression of this gene appears to be brain-specific. Alternative splicing results in multiple transcript variants encoding different isoforms.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000101298 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027457 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Syntaphilin". Retrieved 2016-11-01.

Function

References

Further reading