Stimulator of chondrogenesis 1

SCRG1
Identifiers
Aliases	SCRG1, SCRG-1, stimulator of chondrogenesis 1
External IDs	OMIM: 603163; MGI: 1328308; HomoloGene: 5269; GeneCards: SCRG1; OMA:SCRG1 - orthologs
Gene location (Human) Chr. Chromosome 4 (human) Band 4q34.1 Start 173,384,701 bp End 173,406,380 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8 B2|8 29.8 cM Start 57,908,957 bp End 57,930,619 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibia external globus pallidus subthalamic nucleus saphenous vein inferior ganglion of vagus nerve pars reticulata optic nerve cartilage tissue superior vestibular nucleus pons Top expressed in granulocyte optic nerve lumbar subsegment of spinal cord globus pallidus anterior amygdaloid area superior frontal gyrus dentate gyrus of hippocampal formation granule cell cerebellar cortex entorhinal cortex cerebellar vermis More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component Golgi apparatus neuron projection terminus extracellular region cytoplasm extracellular space Biological process nervous system development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11341 20284 Ensembl ENSG00000164106 ENSMUSG00000031610 UniProt O75711 O88745 RefSeq (mRNA) NM_007281 NM_001329597 NM_009136 RefSeq (protein) NP_001316526 NP_009212 NP_033162 Location (UCSC) Chr 4: 173.38 – 173.41 Mb Chr 8: 57.91 – 57.93 Mb PubMed search
Wikidata
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Stimulator of chondrogenesis 1 is a protein that in humans is encoded by the SCRG1 gene.

Function

Scrapie-responsive gene 1 is associated with neurodegenerative changes observed in transmissible spongiform encephalopathies. It may play a role in host response to prion-associated infections. The scrapie responsive protein 1 may be partly included in the membrane or secreted by the cells due to its hydrophobic N-terminus. In addition, the encoded protein can interact with bone marrow stromal cell antigen 1 (BST1) to enhance the differentiation potentials of human mesenchymal stem cells during tissue and bone regeneration. [provided by RefSeq, Jul 2016].

Further reading

• Aomatsu E, Takahashi N, Sawada S, Okubo N, Hasegawa T, Taira M, Miura H, Ishisaki A, Chosa N (January 2014). "Novel SCRG1/BST1 axis regulates self-renewal, migration, and osteogenic differentiation potential in mesenchymal stem cells". Sci Rep. 4: 3652. Bibcode:2014NatSR...4E3652A. doi:10.1038/srep03652. PMC 3888969. PMID 24413464.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.