Jump to content

Illumina, Inc.

Coordinates: 32°53′15″N 117°10′23″W / 32.8875924°N 117.1730577°W / 32.8875924; -117.1730577
From Wikipedia, the free encyclopedia
(Redirected from Solexa)
Illumina, Inc.
Company typePublic
IndustryBiotechnology
Founded1998; 26 years ago (1998)
Founders
Headquarters
San Diego, California
,
U.S.
Key people
Products
  • NovaSeq
  • HiSeq
  • MiSeq
  • MiniSeq
  • iSeq
  • NextSeq
  • iScan
  • COVIDSeq
  • VeriSeq
  • DRAGEN
  • Illumina Connected Analytics
  • TruSight Oncology
RevenueDecrease US$4.50 billion (2023)
Negative increase US$−1.1 billion (2023)
Negative increase US$−1.2 billion (2023)
Total assetsDecrease US$10.1 billion (2023)
Total equityDecrease US$5.75 billion (2023)
Number of employees
approx. 9,250 (2023)
Websiteillumina.com
Footnotes / references
[1]

Illumina, Inc. is an American biotechnology company, headquartered in San Diego, California. Incorporated on April 1, 1998, Illumina develops, manufactures, and markets integrated systems for the analysis of genetic variation and biological function. The company provides a line of products and services that serves the sequencing, genotyping and gene expression, and proteomics markets, and serves more than 155 countries.[2]

Illumina's customers include genomic research centers, pharmaceutical companies, academic institutions, clinical research organizations, and biotechnology companies.[1]

History

[edit]
Czarnik, Stuelpnagel, and Chee at their Illumina office in the summer of 1998

Illumina was founded in April 1998 by David Walt, Larry Bock, John Stuelpnagel, Anthony Czarnik, and Mark Chee. While working with CW Group, a venture-capital firm, Bock and Stuelpnagel uncovered what would become Illumina's BeadArray technology[3] at Tufts University and negotiated an exclusive license to that technology. In 1999, Illumina acquired Spyder Instruments[4] (founded by Michal Lebl, Richard Houghten, and Jutta Eichler) for their technology of high-throughput synthesis of oligonucleotides. Illumina completed its initial public offering in July 2000.[5]

Illumina began offering single nucleotide polymorphism (SNP) genotyping services in 2001 and launched its first system, the Illumina BeadLab, in 2002, using GoldenGate Genotyping technology. Illumina currently offers microarray-based products and services for an expanding range of genetic analysis sequencing, including SNP genotyping, gene expression, and protein analysis. Illumina's technologies are used by a broad range of academic, government, pharmaceutical, biotechnology, and other leading institutions around the globe.

On January 26, 2007, the company completed the acquisition of the British company Solexa, Inc. for ~$650M.[6] Solexa was founded in June 1998 by Shankar Balasubramanian and David Klenerman to develop and commercialize genome-sequencing technology invented by the founders at the University of Cambridge. Solexa, Inc. was formed in 2005 when Solexa Ltd reversed into Lynx Therapeutics of Hayward.[7] Illumina also uses the DNA colony sequencing technology, invented in 1997 by Pascal Mayer and Laurent Farinelli [8] and which was acquired by Solexa in 2004 from Manteia Predictive Medicine. It is being used to perform a range of analyses, including whole genome resequencing, gene-expression analysis, and small ribonucleic acid (sRNA) analysis.

In June 2009, Illumina announced the launch of their own Personal Full Genome Sequencing Service at a depth of 30X.[9]

Until 2010, Illumina sold only instruments that were labeled "for research use only"; in early 2010, Illumina obtained FDA approval for its BeadXpress system to be used in clinical tests.[10][11] This was part of the company's strategy at the time to open its own CLIA lab and begin offering clinical genetic testing itself.[12]

Illumina acquired Epicentre Biotechnologies, based in Madison, Wisconsin, on January 11, 2011.[13] On January 25, 2012, Hoffmann-La Roche made an unsolicited bid to buy Illumina for $44.50 per share or about $5.7 billion.[14][15] Roche tried other tactics, including raising its offer (to $51.00, for about $6.8 billion).[16] Illumina rejected the offer,[17] and Roche abandoned the offer in April.[18]

In 2014, the company announced a multimillion-dollar product, HiSeq X Ten.[19][20] In January 2014, Illumina already held 70% of the market for genome-sequencing machines.[21] Illumina machines accounted for more than 90% of all DNA data produced.[22] In 2020, the company invested in the acquisition of the pre-commercial firm Enancio, which had developed a DNA data compression algorithm specifically targeting Illumina data capable of reducing storage footprint by 80% (e.g. 50 GB compressed to 10 GB).[23]

On July 5, 2016, Jay Flatley, who had been CEO since 1999, assumed the role of executive chairman of the board of directors. Francis deSouza, who had been president of the company since 2013, took on the additional role of CEO.[24]

In late 2015, Illumina spun off the company Grail, focused on blood testing for cancer tumors in the bloodstream. In 2017 Grail had planned to raise $1 billion in its second round of financing, and received funding from Bill Gates and Jeff Bezos investing $100 million in series A funding, and with Illumina maintaining a 20% holding share in Grail.[25] Grail is working with a blood test trial with over 120,000 women during scheduled mammogram visits in the states of Minnesota and Wisconsin, as well as a partnership with the Mayo Clinic. Grail uses Illumina sequencing technology for tests.[26] Grail planned to roll out the tests by 2019.[27] In September 2020, Illumina announced a proposed cash and stock deal to acquire Grail for $8 billion.[28][29]

In November 2018, Illumina proposed the acquisition of Pacific Biosciences for $8.00 per share or around $1.2 billion in total.[30][31] In December 2019, the Federal Trade Commission (FTC) sued to block the acquisition.[32] The proposed deal was abandoned on January 2, 2020, with Illumina paying Pacific a $98 million termination fee.[33]

In March 2021, the FTC sued to block Illumina's $7.1 billion vertical merger with Grail.[34][35] In July 2021, the European Commission opened an in-depth investigation into the Grail acquisition by Illumina.[36] Against the orders of active investigations by both the US FTC and the EU European Commission, Illumina publicly announced it had completed its acquisition of Grail on August 18, 2021.[37] The FTC urged Illumina to "unwind" the merger shortly after,[38] and in October 2021, the European Commission ordered Illumina to keep Grail a separate company[39] and adopted interim measures to prevent harm to competition, or face penalty payments up to 5% of their average daily turnover and/or fines up to 10% of their annual worldwide turnover under Articles 15 and 14 of the EU Merger Regulation respectively.[36] In September 2022, a US administrative judge ruled against the FTC's efforts to prevent the acquisition on antitrust grounds.[40] In April 2023, the FTC ordered Grail to be divested by Illumina.[41] In July 2023, the European Commission imposed a €432 million ($476 million) penalty on Illumina for closing the Grail acquisition without EU approval.[42]

In September 2022, Illumina launched NovaSeq X and NovaSeq X Plus.[43] The NovaSeq X Plus can sequence 20,000 genomes per year, compared to 7,500 per year of Illumina's previous machines and generate up to 16 Tb of data per run.[43] The series includes redeveloped reagents, dyes, and polymerases which can be shipped at ambient temperature.[44]

In June 2023, deSouza resigned as CEO of Illumina, and was replaced by interim CEO Charles Dadswell, the company's general counsel.[45] Also in June 2023, Hologic CEO Stephen Macmillan was named non-executive Chairman of the Board of Directors.[46]

In September 2023, Agilent Technologies' senior vice president Jacob Thaysen was appointed CEO.[47]

In October 2023, the European Commission ordered Grail to be divested from Illumina within the next twelve months.[48] Illumina said it would explore a third-party sale or a capital markets transaction if it fails to win its ongoing challenge in court.[49] In June 2024 Illumina has completed the spin-off of Grail, keeping only a minority stake of 14.5%.[50] The 2022 appeal in the case against the European Commission has been settled in September 2024 in favour of Illumina and declaring the merger outside the Commissions jurisdiction. With the repealed decision Illumina concluded the fine to be void.[51]

Acquisition history

[edit]

The following is an illustration of the company's mergers, acquisitions, spin-offs and historical predecessors:

  • Illumina, Inc.
    • Spyder Instruments (Acq 1999)
    • CyVera, Inc. (Acq 2005)
    • Solexa, Inc. (Acq 2007)
      • Solexa Ltd (Merged 2005)
      • Lynx Therapeutics Inc. (Merged 2005)
    • Avantome Inc. (Acq 2008)
    • Helixis, Inc. (Acq 2010)
    • Epicentre Biotechnologies (Acq 2011)
    • BlueGnome (Acq 2012)
    • Verinata Health, Inc. (Acq 2013)
    • Advanced Liquid Logic (Acq 2013)
    • NextBio (Acq 2013)
    • Myraqa (Acq 2014)
    • GenoLogics Life Sciences Software Inc. (Acq 2015)
    • Conexio Genomics (Acq 2016)
    • Edico Genome (Acq 2018)
    • Enancio (Acq 2020)
    • BlueBee (Acq 2020)
    • Emedgene (Acq 2021)
    • IDbyDNA (Acq 2022)
    • Partek Inc. (Acq 2023)
    • Fluent (Acq 2024)

Products

[edit]

DNA sequencing

[edit]
Main articles: Illumina (Solexa) sequencing and Illumina dye sequencing
Illumina MiSeq sequencer

Illumina sells a number of high-throughput DNA sequencing systems, also known as DNA sequencers, based on technology developed by Solexa. The technology features bridge amplification to generate clusters and reversible terminators for sequence determination.[52][53] The technology behind these sequencing systems involves ligation of fragmented DNA to a chip, followed by primer addition and sequential fluorescent dNTP incorporation and detection.

Depending on the kit used, according to the company the MiSeq Series generates up to 25 million reads per run.[54] With dual flow cells, the NextSeq 2000 generates up to 2.4 billion single reads per run[55] and the NovaSeq X Series generates up to 52 billion single reads per run.[56] Illumina uses next-generation sequencing, which is far faster and more efficient than traditional Sanger sequencing.[57] Illumina sequencers perform short-read sequencing, and are image based, utilizing Illumina dye sequencing.[57] This technology has a higher accuracy than long-read sequencing.[57]

Flow cells

[edit]
MiSeq Flow Cell (Top)
NovaSeq Flow Cell

Illumina sequencing happens within the flow cells. These flow cells are small in size and are housed in the flow cell compartment. Flow cell clustering happens when a denatured DNA sample is placed in a flow cell. Primers already in the flow cell channel capture and bind to the ends of the short denatured DNA sample. Then, DNA polymerase is added and the DNA building blocks are introduced. This results in a newly synthesized strand constrained to the bottom of the flow cell. Next, the original template strand is washed out binding the newly synthesized strand to the other DNA sequence present on the surface. DNA polymerase and building blocks are introduced again forming a new strand. These steps are repeated until about 1,000 copies are made in a cluster.[57]

Litigation

[edit]

Czarnik suit against Illumina

[edit]

In 2005, co-founder and former Chief Scientific Officer Anthony Czarnik sued Illumina. In the case, Czarnik v. Illumina Inc., the trial court granted Illumina's motion to dismiss in part but allowed Czarnik's correction of inventorship claims to continue.[58]

Cornell University and Life Technologies suit against Illumina

[edit]

In 2010, Cornell University and Life Technologies filed a lawsuit against Illumina, alleging that its microarray products infringed on eight patents held by the university and exclusively licensed to the start-up. The case was settled in April 2017 without any finding of fault. In September 2017 both parties asked to have the settlement reviewed, with Cornell accusing both Illumina and Life Technologies of misrepresentation and fraud.[59] Cornell claimed that ThermoFisher had promised to settle the suit with Illumina and asked for the Markman wording to be dropped so that it could file a subsequent suit involving other patents invented at Cornell. Instead of filing the suit, ThermoFisher and Illumina settled another lawsuit in California and secretly sublicensed those very same patents. In 2018, Dr. Monib Zirvi filed a lawsuit in the Southern District of New York against Illumina and some of its key employees claiming that they knowingly incorporated ideas and ZipCode DNA sequences invented in the Barany Lab in Illumina's patent applications. Although this suit was dismissed, it was only after Illumina and its attorneys claimed that some of those IP misappropriation were “storm warnings” and thus statutes of limitations had run out on those particular claims. Dr. Monib Zirvi also filed a FOIA case in New Jersey in 2020 for unredacted copies for key NIH grants that Illumina filed early in its existence. William Noon, an in-house attorney at Illumina, had filed a FOIA request for 4 of these key grants as well in January 2015.

Patent infringement suits

[edit]

Illumina was a party in a patent lawsuit against competitor Ariosa Diagnostics. The litigation began in 2012 with Verinata Health filing suit against Ariosa. Illumina joined the suit after acquiring Verinata in 2013. Ariosa subsequently brought a counterclaim against Illumina.[60] The trial court granted summary judgment in favor of Ariosa, but the United States Court of Appeals for the Federal Circuit reversed.[61] Ariosa initially pursued an appeal to the Supreme Court of the United States, but the two parties resolved the dispute before the Court decided whether to take the case.[62]

In February 2016, Illumina filed a lawsuit against Oxford Nanopore Technologies. Illumina claimed that Oxford Nanopore infringed its patents on the use of a biological nanopore, Mycobacterium smegmatis porinA (MspA), for sequencing systems.[63][64] In August 2016 the parties settled their lawsuit.[65]

In February 2020, Illumina filed a patent infringement suit against BGI relating to its "CoolMPS" sequencing products.[66] In return BGI has filed patent infringement lawsuits for violation of federal antitrust and California unfair competition laws, claiming use of "fraudulent behavior" to obtain or enforce sequencing patents that it has asserted against BGI, preventing the firm from entering the US market.[67] However, in May 2022, Illumina was ordered to pay $333 million to a U.S. unit of BGI in California for infringing two patents of DNA-sequencing systems. The jury of the case also said that Illumina willfully infringed the patents, and that their former accusation of BGI's infringement was invalid.[68]

On May 6, 2022, a jury in the U.S. District Court for the District of Delaware rendered a verdict that Illumina willfully infringed two patents owned by Complete Genomics, and awarded approximately $334 million to CGI in past damages. The jury also invalidated three patents owned by Illumina.[69]

Trade secrets suit against Eltoukhy and Talasaz

[edit]

In March 2022, Illumina sued Helmy Eltoukhy and Amir Talasaz, the co-founders of Guardant, over stealing trade secrets.[70] Guardant called the lawsuit "frivolous and retaliatory" and framed it as a response to its concerns about the Illumina-Grail merger.[70] Guardant also claimed the lawsuit was filed in order to suppress competition in the marketplace.[71]

References

[edit]
  1. ^ a b "US SEC:Form 10-K Illumina, Inc". U.S. Securities and Exchange Commission. 16 February 2024. Archived from the original on 17 February 2024. Retrieved 17 February 2024.
  2. ^ Morrison, Mary E. (May 31, 2023). "At Illumina, Breaking DownBarriers to Democratize Genomics". Wall Street Journal. Deloitte. Archived from the original on November 8, 2023. Retrieved November 8, 2023.
  3. ^ "Illumina- The Origin story". www.linkedin.com. Archived from the original on 2024-05-10. Retrieved 2020-10-05.
  4. ^ "Spyder Instruments, Inc". www.kvinzo.com. Retrieved 2024-12-27.
  5. ^ Stipp, David (3 Apr 2000). "13 Biotech IPOs To Watch For". Fortune. Retrieved 4 Nov 2019.
  6. ^ Devlin, Hannah (3 April 2020). "Why has the UK lagged behind in testing for the Coronavirus?". The Guardian. Archived from the original on 10 May 2024. Retrieved 21 April 2020.
  7. ^ "History of Illumina Sequencing". illumina.com. Archived from the original on 2017-02-02. Retrieved 2017-01-25.
  8. ^ Kawashima, Eric H.; Laurent Farinelli; Pascal Mayer (2005-05-12). "Patent: Method of nucleic acid amplification". Archived from the original on 2013-02-22. Retrieved 2012-12-22.
  9. ^ Everygenome.com: Individual genome sequencing - Illumina, Inc. Archived 2011-10-19 at the Wayback Machine
  10. ^ Petrone, Justin (May 4, 2010). "FDA Clears Illumina's BeadXpress System for Clinical Use". GenomeWeb. Archived from the original on November 4, 2020. Retrieved April 7, 2017.
  11. ^ "510(k) Premarket Notification K093128". FDA. Archived from the original on 4 November 2020. Retrieved 7 April 2017.
  12. ^ "Big Array Vendors Promise New Chips, Acquisitions, and Diagnostics in 2009". GenomeWeb. January 6, 2009. Archived from the original on September 11, 2019. Retrieved April 7, 2017.
  13. ^ "Illumina .::. Investor Relations News Release". Investor.illumina.com. 2011-01-11. Archived from the original on 2013-11-21. Retrieved 2014-01-18.
  14. ^ "Roche - Roche offers to acquire all outstanding shares of Illumina, Inc. to further strengthen its leading role in diagnostics". Archived from the original on 2012-02-28. Retrieved 2012-03-07.
  15. ^ "Xconomy: Five Reasons Illumina Should Fight Roche's Insulting Low-Ball Bid". Xconomy. 5 March 2012. Archived from the original on 10 May 2024. Retrieved 4 June 2019.
  16. ^ Roche and Illumina: Taking it personally Archived 2018-02-06 at the Wayback Machine. The Economist (2012-04-18). Retrieved on 2013-09-05.
  17. ^ "Illumina Board Rejects Roche's Hostile Tender". MondayMorning. 20 (7): 1. February 2012.
  18. ^ Roche decides not to extend its tender offer for Illumina, Inc. Archived 2014-08-08 at the Wayback Machine
  19. ^ Clark, Liat (15 Jan 2014). "Illumina announces landmark $1,000 human genome sequencing". Wired. Archived from the original on 4 November 2019. Retrieved 4 Nov 2019.
  20. ^ Molteni, Megan (19 Nov 2018). "Now You Can Sequence Your Whole Genome for Just $200". Wired. Archived from the original on 8 November 2020. Retrieved 4 Nov 2019.
  21. ^ Zimmerman, Eilene (18 February 2014). "50 Smartest Companies: Illumina". MIT Technology Review. Massachusetts Institute of Technology. Archived from the original on 11 December 2015. Retrieved 25 August 2014.
  22. ^ Regalado, Antonio. "EmTech: Illumina Says 228,000 Human Genomes Will Be Sequenced This Year". MIT Technology Review. Massachusetts Institute of Technology. Archived from the original on 26 December 2015. Retrieved 26 September 2014.
  23. ^ Staff (15 July 2020). "Illumina Acquires French Genomic Data-Compression Startup Enancio". GenomeWeb. New York City: Crain Communications. Archived from the original on 17 July 2020. Retrieved 16 July 2020.
  24. ^ Stone, Ken (March 7, 2016). "Illumina likes Francis deSouza's DNA, elevating president to CEO". Times of San Diego. Archived from the original on December 4, 2022. Retrieved November 8, 2023.
  25. ^ Herper, Matthew. "Company Will Raise $1 Billion To Create Blood Test To Detect Cancer". Forbes. Archived from the original on 2020-12-06. Retrieved 2017-04-30.
  26. ^ "Mayo Clinc scientists on the trail of a 'pan cancer' test". Star Tribune. Archived from the original on 2020-08-09. Retrieved 2017-04-30.
  27. ^ Swanson, Cheryl (2017-04-30). "Are Jeff Bezos and Bill Gates Wrong About Illumina? -- The Motley Fool". The Motley Fool. Archived from the original on 2020-10-25. Retrieved 2017-04-30.
  28. ^ "Illumina to buy Jeff Bezos-backed cancer testing firm Grail in £6.23 billion deal". Reuters. 21 September 2020.[dead link‍]
  29. ^ Farr, Christina (2020-09-21). "Illumina buys Jeff Bezos-backed cancer-testing firm Grail in deal worth $8 billion". CNBC. Archived from the original on 2020-09-29. Retrieved 2020-09-22.
  30. ^ "Illumina to Acquire Pacific Biosciences for Approximately $1.2 Billion, Broadening Access to Long-Read Sequencing and Accelerating Scientific Discovery". BioSpace. Archived from the original on 2019-06-04. Retrieved 2019-06-04.
  31. ^ "Illumina Acquires Pacific Biosciences for $1.2 Billion". BioSpace. Archived from the original on 2019-01-15. Retrieved 2018-11-03.
  32. ^ "FTC Challenges Illumina's Proposed Acquisition of PacBio". Federal Trade Commission. 17 December 2019. Archived from the original on 30 March 2021. Retrieved 31 March 2021.
  33. ^ "Illumina abandons $1.2 billion deal to buy rival Pacific Biosciences". CNBC. 2020-01-02. Archived from the original on 2020-01-03. Retrieved 2020-01-03.
  34. ^ Kendall, Brent; Rockoff, Jonathan D. (31 March 2021). "FTC Seeks to Block Illumina's $7.1 Billion Acquisition of Life Sciences Firm Grail". Wall Street Journal. Archived from the original on 30 March 2021. Retrieved 31 March 2021.
  35. ^ "FTC Challenges Illumina's Proposed Acquisition of Cancer Detection Test Maker Grail". Federal Trade Commission. 30 March 2021. Archived from the original on 30 March 2021. Retrieved 31 March 2021.
  36. ^ a b "Press corner". European Commission - European Commission. Archived from the original on 2019-06-21. Retrieved 2021-12-28.
  37. ^ "Illumina completes Grail acquisition, regulators be damned". FierceBiotech. 19 August 2021. Archived from the original on 2021-12-28. Retrieved 2021-12-28.
  38. ^ Scarcella, Mike (2021-08-24). "FTC urges judge to unwind $7.1 bln Illumina-Grail merger". Reuters. Archived from the original on 2021-12-28. Retrieved 2021-12-28.
  39. ^ "EU orders Illumina to keep Grail a separate company". Reuters. 2021-10-29. Retrieved 2021-12-28.
  40. ^ Loftus, Peter (1 September 2022). "Illumina Wins Case Against FTC on Grail Acquisition". The Wall Street Journal. Archived from the original on 1 September 2022. Retrieved 1 September 2022.
  41. ^ Lohr, Steve (3 April 2023). "F.T.C. Orders Gene-Sequencing Company Illumina to Divest Acquisition". The New York Times. Archived from the original on 4 April 2023. Retrieved 4 April 2023.
  42. ^ Chee, Foo Yun (12 July 2023). "Illumina hit with record $476 million EU antitrust fine over Grail deal". Reuters. Archived from the original on 2023-07-13. Retrieved 2023-07-13.
  43. ^ a b Mullin, Emily (September 29, 2022). "The Era of Fast, Cheap Genome Sequencing Is Here". Wired. Archived from the original on February 8, 2023. Retrieved February 8, 2023.
  44. ^ Hale, Conor (September 30, 2022). "Illumina pitches $200 genomes with new line of DNA sequencers". FierceBiotech. Archived from the original on February 23, 2023. Retrieved February 8, 2023.
  45. ^ Loftus, Peter (June 11, 2023). "Illumina CEO Francis deSouza Resigns Amid Regulatory Hurdles, Proxy Fight". Wall Street Journal. Archived from the original on June 16, 2023. Retrieved June 16, 2023.
  46. ^ "Illumina expands board after fight with Icahn". Reuters. June 2, 2023. Archived from the original on 2023-08-10. Retrieved 2023-08-09.
  47. ^ Rocha, Natallie (September 6, 2023). "San Diego has a new CEO in town. Here's what financial analysts are saying about Illumina's next leader". San Diego Union-Tribune. Archived from the original on November 8, 2023. Retrieved November 8, 2023.
  48. ^ Chee, Foo Yun (October 12, 2023). "Illumina ordered by EU antitrust regulators to sell Grail". Reuters. Archived from the original on 2023-10-19. Retrieved 2023-10-14.
  49. ^ Roy, Sriparna (October 13, 2023). "Illumina to divest Grail within a year if it does not win challenge in EU court". Reuters.
  50. ^ Steenhuysen, Julie (June 25, 2024). "Grail bets big on flagship cancer test after spin-off from Illumina". Reuters.
  51. ^ Chee, Foo Yun (September 3, 2024). "Illumina wins Grail battle in blow to EU merger power". Reuters.
  52. ^ S Balasubramanian RSC Chem. Commun., 47 (26), 7281-7286 (2011)
  53. ^ Bentley, David R.; et al. (6 November 2008). "Accurate whole human genome sequencing using reversible terminator chemistry". Nature. 456 (7218): 53–59. Bibcode:2008Natur.456...53B. doi:10.1038/nature07517. PMC 2581791. PMID 18987734.
  54. ^ "Illumina sequencing platforms". Illumina. Archived from the original on February 4, 2023. Retrieved February 8, 2023.
  55. ^ "NextSeq 1000 and NextSeq 2000 Overview". Illumina. Archived from the original on February 8, 2023. Retrieved February 8, 2023.
  56. ^ "NovaSeq X and NovaSeq X Plus Sequencing Systems" (PDF). Illumina. Archived (PDF) from the original on February 8, 2023. Retrieved February 8, 2023.
  57. ^ a b c d "Next Generation Sequencing • iBiology". iBiology. Archived from the original on 2020-08-01. Retrieved 2020-05-15.
  58. ^ Czarnik v. Illumina, Inc., 437 F. Supp. 2d 252 (D. Del. 2006).
  59. ^ "Cornell revives previously settled patent infringement lawsuit against Illumina". 20 September 2017. Archived from the original on 18 May 2018. Retrieved 8 July 2018.
  60. ^ Bayles, Cara (23 January 2018). "Illumina, Ariosa Seek Tens Of Millions As IP Trial Ends". Law360. Archived from the original on 8 October 2022. Retrieved 8 October 2022.
  61. ^ Illumina, Inc. v. Ariosa Diagnostics, Inc., 967 F.3d 1319 (Fed. Cir. 2020).
  62. ^ Kass, Dani (24 May 2021). "Ariosa, Illumina Resolve DNA Patent Dispute At High Court". Law360. Archived from the original on 8 October 2022. Retrieved 8 October 2022.
  63. ^ Check Hayden, Erika (25 February 2016). "Fight brews over promising genetic-sequencing technology". Nature: nature.2016.19451. doi:10.1038/nature.2016.19451. S2CID 211836642.
  64. ^ "Illumina sues Oxford Nanopore for patent infringement".[permanent dead link‍]
  65. ^ "Illumina and Oxford Nanopore Settle Patent Infringement Lawsuit". GenomeWeb. 25 August 2016. Archived from the original on 2021-01-14. Retrieved 2021-01-13.
  66. ^ "Illumina Files Additional Patent Infringement Suit Against BGI in the U.S." BioSpace. Archived from the original on 2020-08-01. Retrieved 2021-01-13.
  67. ^ "BGI Sues Illumina for Antitrust Violation, Claims Firm Obtained Sequencing Patents Through Fraud". GenomeWeb. 11 January 2021. Archived from the original on 2021-01-11. Retrieved 2021-01-13.
  68. ^ Brittain, Blake (2022-05-07). "Illumina ordered to pay BGI subsidiary $333 million in DNA-sequencing patent case". Reuters. Archived from the original on 2022-05-11. Retrieved 2022-05-07.
  69. ^ Patchen, Tyler. "Illumina forced to pay almost $334M as it loses DNA sequencing patent case". Endpoints News. Archived from the original on 2022-05-09. Retrieved 2022-05-10.
  70. ^ a b "Illumina sues Guardant CEOs over trade secrets, sparking counterblast against 'retaliatory' lawsuit". MedTech Dive. Archived from the original on 2022-10-20. Retrieved 2022-10-20.
  71. ^ "Guardant Health fires back at Illumina suit, claiming retaliation over its role in FTC antitrust investigation". Endpoints News. Archived from the original on 2022-10-20. Retrieved 2022-10-20.
[edit]
Wikimedia Commons has media related to Illumina (company).

32°53′15″N 117°10′23″W / 32.8875924°N 117.1730577°W / 32.8875924; -117.1730577

Retrieved from "https://wiki.riteme.site/w/index.php?title=Illumina,_Inc.&oldid=1265573951"