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Small nucleolar RNA SNORA75

From Wikipedia, the free encyclopedia
Small nucleolar RNA SNORA75
Identifiers
SymbolSNORA75
Alt. SymbolsU23
RfamRF00072
Other data
RNA typeGene; snRNA; snoRNA; H/ACA-box
Domain(s)Eukaryota
GOGO:0006396 GO:0005730
SOSO:0000594
PDB structuresPDBe

In molecular biology, U23 belongs to the H/ACA class of snoRNAs. snoRNAs bind a number of proteins (including dyskerin, Gar1p and Nop10p in the case of the H/ACA class) to form snoRNP complexes. This class are thought to guide the sites of modification of uridines to pseudouridines by forming direct base pairing interactions with substrate RNAs.[1] Targets include ribosomal and spliceosomal RNAs as well as the Trypanosoma spliced leader RNA (SL RNA) as possibly other, still unknown cellular RNAs.[1] U23 can direct the pseudouridylation of U97 in human 18S rRNA. U23 is encoded within intron 12 of the nucleolin gene in human, mouse, rat chicken, and Xenopus laevis.

References

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  1. ^ a b Kiss T (April 2002). "Small nucleolar RNAs: an abundant group of noncoding RNAs with diverse cellular functions". Cell. 109 (2): 145–8. doi:10.1016/S0092-8674(02)00718-3. PMID 12007400. S2CID 8968788.

Further reading

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