SYNJ2BP

SYNJ2BP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2ENO, 2JIK, 2JIN
Identifiers
Aliases	SYNJ2BP, ARIP2, OMP25, synaptojanin 2 binding protein
External IDs	OMIM: 609411; MGI: 1344347; HomoloGene: 10161; GeneCards: SYNJ2BP; OMA:SYNJ2BP - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	70,417,090 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	81,579,685 bp
RNA expression pattern
	Top expressed in
	renal medulla; ; cardia; ; body of tongue; ; pylorus; ; saphenous vein; ; biceps brachii; ; jejunum; ; vena cava; ; Skeletal muscle tissue of biceps brachii; ; Skeletal muscle tissue of rectus abdominis;
	Top expressed in
	tunica media of zone of aorta; ; intercostal muscle; ; digastric muscle; ; sternocleidomastoid muscle; ; temporal muscle; ; ciliary body; ; triceps brachii muscle; ; saccule; ; otic placode; ; epithelium of stomach;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; protein C-terminus binding; ionotropic glutamate receptor binding;
Cellular component	integral component of membrane; mitochondrial outer membrane; membrane; mitochondrion; integral component of mitochondrial outer membrane; ionotropic glutamate receptor complex; basolateral plasma membrane; cell junction; neuromuscular junction; neuron projection; postsynaptic density membrane;
Biological process	negative regulation of endothelial cell migration; negative regulation of angiogenesis; regulation of Notch signaling pathway; negative regulation of endothelial cell proliferation; negative regulation of sprouting angiogenesis; negative regulation of ERK1 and ERK2 cascade; protein targeting; Rho protein signal transduction; regulation of endocytosis; intracellular distribution of mitochondria; chemical synaptic transmission; receptor clustering; establishment or maintenance of epithelial cell apical/basal polarity; receptor localization to synapse; cell-cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	55333
	24071
	ENSG00000213463
	ENSMUSG00000090935
	P57105
	Q9D6K5
	NM_018373
	NM_025292; NM_001309814
	NP_060843
	NP_001296743; NP_079568
	Wikidata
View/Edit Human	View/Edit Mouse

Synaptojanin-2-binding protein is a protein that in humans is encoded by the SYNJ2BP gene.^[5]^[6]

Interactions

SYNJ2BP has been shown to interact with:

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000213463 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000090935 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b ^c Matsuzaki T, Hanai S, Kishi H, Liu Z, Bao Y, Kikuchi A, Tsuchida K, Sugino H (May 2002). "Regulation of endocytosis of activin type II receptors by a novel PDZ protein through Ral/Ral-binding protein 1-dependent pathway". The Journal of Biological Chemistry. 277 (21): 19008–18. doi:10.1074/jbc.M112472200. PMID 11882656.
^ "Entrez Gene: SYNJ2BP synaptojanin 2 binding protein".
^ Tsuchida K, Nakatani M, Matsuzaki T, Yamakawa N, Liu Z, Bao Y, Arai KY, Murakami T, Takehara Y, Kurisaki A, Sugino H (Oct 2004). "Novel factors in regulation of activin signaling". Molecular and Cellular Endocrinology. 225 (1–2): 1–8. doi:10.1016/j.mce.2004.02.006. PMID 15451561. S2CID 34666659.
^ ^a ^b Gotthardt M, Trommsdorff M, Nevitt MF, Shelton J, Richardson JA, Stockinger W, Nimpf J, Herz J (Aug 2000). "Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction". The Journal of Biological Chemistry. 275 (33): 25616–24. doi:10.1074/jbc.M000955200. PMID 10827173.

Nemoto Y, De Camilli P (Jun 1999). "Recruitment of an alternatively spliced form of synaptojanin 2 to mitochondria by the interaction with the PDZ domain of a mitochondrial outer membrane protein". The EMBO Journal. 18 (11): 2991–3006. doi:10.1093/emboj/18.11.2991. PMC 1171381. PMID 10357812.
Gotthardt M, Trommsdorff M, Nevitt MF, Shelton J, Richardson JA, Stockinger W, Nimpf J, Herz J (Aug 2000). "Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction". The Journal of Biological Chemistry. 275 (33): 25616–24. doi:10.1074/jbc.M000955200. PMID 10827173.
Weins A, Schwarz K, Faul C, Barisoni L, Linke WA, Mundel P (Oct 2001). "Differentiation- and stress-dependent nuclear cytoplasmic redistribution of myopodin, a novel actin-bundling protein". The Journal of Cell Biology. 155 (3): 393–404. doi:10.1083/jcb.200012039. PMC 2150840. PMID 11673475.
Lin F, Yu YP, Woods J, Cieply K, Gooding B, Finkelstein P, Dhir R, Krill D, Becich MJ, Michalopoulos G, Finkelstein S, Luo JH (Nov 2001). "Myopodin, a synaptopodin homologue, is frequently deleted in invasive prostate cancers". The American Journal of Pathology. 159 (5): 1603–12. doi:10.1016/S0002-9440(10)63006-4. PMC 3277320. PMID 11696420.
Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (Sep 2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Research. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Tsuchida K, Nakatani M, Matsuzaki T, Yamakawa N, Liu Z, Bao Y, Arai KY, Murakami T, Takehara Y, Kurisaki A, Sugino H (Oct 2004). "Novel factors in regulation of activin signaling". Molecular and Cellular Endocrinology. 225 (1–2): 1–8. doi:10.1016/j.mce.2004.02.006. PMID 15451561. S2CID 34666659.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000213463 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000090935 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11882656-5] Matsuzaki T, Hanai S, Kishi H, Liu Z, Bao Y, Kikuchi A, Tsuchida K, Sugino H (May 2002). "Regulation of endocytosis of activin type II receptors by a novel PDZ protein through Ral/Ral-binding protein 1-dependent pathway". The Journal of Biological Chemistry. 277 (21): 19008–18. doi:10.1074/jbc.M112472200. PMID 11882656.

[entrez-6] "Entrez Gene: SYNJ2BP synaptojanin 2 binding protein".

[pmid15451561-7] Tsuchida K, Nakatani M, Matsuzaki T, Yamakawa N, Liu Z, Bao Y, Arai KY, Murakami T, Takehara Y, Kurisaki A, Sugino H (Oct 2004). "Novel factors in regulation of activin signaling". Molecular and Cellular Endocrinology. 225 (1–2): 1–8. doi:10.1016/j.mce.2004.02.006. PMID 15451561. S2CID 34666659.

[pmid10827173-8] Gotthardt M, Trommsdorff M, Nevitt MF, Shelton J, Richardson JA, Stockinger W, Nimpf J, Herz J (Aug 2000). "Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction". The Journal of Biological Chemistry. 275 (33): 25616–24. doi:10.1074/jbc.M000955200. PMID 10827173.

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Interactions

References

Further reading