SURF4
Surfeit locus protein 4 or Surf4 is a protein involved in regulating export of some proteins from the endoplasmic reticulum to the golgi bodies.[4][5] Surf4 is involved in trafficking soluble (i.e. non-membrane-bound) proteins, namely lipoproteins and PCSK9.[4] It recognizes cargo proteins via a three-amino-acid sequence near the N-termini.[4] The related protein in yeast is called Erv29p.[5]
This gene is named based on its location in the surfeit gene cluster, composed of six housekeeping genes that do not share sequence similarity. The encoded protein is a conserved integral membrane protein containing multiple putative transmembrane regions. Surf4's yeast homolog is directly required for packaging glycosylated pro-alpha-factor into COPII vesicles.[6]
Eliminating Surf4 in the liver reduces the amount of lipid in the plasma and prevents atherosclerosis in mice.[4]
References
[edit]- ^ a b c ENSG00000280951 GRCh38: Ensembl release 89: ENSG00000148248, ENSG00000280951 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b c d Sun S, Tang X, Guo Y, Hu J (August 2021). "Endoplasmic reticulum composition and form: Proteins in and out". Current Opinion in Cell Biology. 71: 1–6. doi:10.1016/j.ceb.2021.01.008. PMID 33611096. S2CID 231987943.
- ^ a b "SURF4 Gene - Surfeit 4". Retrieved 8 June 2022.
- ^ "Entrez Gene: SURF4 surfeit 4".
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