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Protein-coding gene in the species Homo sapiens
Sulfatase-modifying factor 2 is an enzyme that in humans is encoded by the SUMF2 gene .[ 5] [ 6]
The catalytic sites of sulfatases are only active if they contain a unique amino acid , C-alpha-formylglycine (FGly). The FGly residue is posttranslationally generated from a cysteine by enzymes with FGly-generating activity. The gene described in this record is a member of the sulfatase-modifying factor family and encodes a protein with a DUF323 domain that localizes to the lumen of the endoplasmic reticulum . This protein has low levels of FGly-generating activity but can heterodimerize with another family member - a protein with high levels of FGly-generating activity. Alternate transcriptional splice variants , encoding different isoforms , have been characterized.[ 6]
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