SULT1C4

SULT1C4
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2AD1, 2GWH
Identifiers
Aliases	SULT1C4, SULT1C, SULT1C2, sulfotransferase family 1C member 4
External IDs	OMIM: 608357; HomoloGene: 41383; GeneCards: SULT1C4; OMA:SULT1C4 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	108,388,989 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; gallbladder; ; left ovary; ; right lung; ; ganglionic eminence; ; right ovary; ; right uterine tube; ; hypothalamus; ; canal of the cervix; ; caudate nucleus;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; sulfotransferase activity; aryl sulfotransferase activity;
Cellular component	cytoplasm; cytosol; cellular component;
Biological process	sulfation; ethanol catabolic process; 3'-phosphoadenosine 5'-phosphosulfate metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	27233
	n/a
	ENSG00000198075
	n/a
	O75897
	n/a
	NM_006588; NM_001321770
	n/a
	NP_001308699; NP_006579
	n/a
	Wikidata
View/Edit Human

Sulfotransferase 1C4 is an enzyme that in humans is encoded by the SULT1C4 gene.^[3]^[4]^[5]

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities.

The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that belongs to the SULT1 subfamily, responsible for transferring a sulfo moiety from PAPS to phenol-containing compounds.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000198075 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Freimuth RR, Raftogianis RB, Wood TC, Moon E, Kim UJ, Xu J, Siciliano MJ, Weinshilboum RM (Jul 2000). "Human sulfotransferases SULT1C1 and SULT1C2: cDNA characterization, gene cloning, and chromosomal localization". Genomics. 65 (2): 157–65. doi:10.1006/geno.2000.6150. PMID 10783263.
^ Sakakibara Y, Yanagisawa K, Katafuchi J, Ringer DP, Takami Y, Nakayama T, Suiko M, Liu MC (Jan 1999). "Molecular cloning, expression, and characterization of novel human SULT1C sulfotransferases that catalyze the sulfonation of N-hydroxy-2-acetylaminofluorene". J Biol Chem. 273 (51): 33929–35. doi:10.1074/jbc.273.51.33929. PMID 9852044.
^ ^a ^b "Entrez Gene: SULT1C2 sulfotransferase family, cytosolic, 1C, member 2".

Weinshilboum RM, Otterness DM, Aksoy IA, et al. (1997). "Sulfation and sulfotransferases 1: Sulfotransferase molecular biology: cDNAs and genes". FASEB J. 11 (1): 3–14. doi:10.1096/fasebj.11.1.9034160. PMID 9034160. S2CID 12532583.
Glatt H, Engelke CE, Pabel U, et al. (2000). "Sulfotransferases: genetics and role in toxicology". Toxicol. Lett. 112–113: 341–8. doi:10.1016/S0378-4274(99)00214-3. PMID 10720750.
Glatt H (2001). "Sulfotransferases in the bioactivation of xenobiotics". Chem. Biol. Interact. 129 (1–2): 141–70. doi:10.1016/S0009-2797(00)00202-7. PMID 11154739.
Glatt H, Boeing H, Engelke CE, et al. (2001). "Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects". Mutat. Res. 482 (1–2): 27–40. doi:10.1016/S0027-5107(01)00207-X. PMID 11535246.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
Allali-Hassani A, Pan PW, Dombrovski L, et al. (2007). "Structural and chemical profiling of the human cytosolic sulfotransferases". PLOS Biol. 5 (5): e97. doi:10.1371/journal.pbio.0050097. PMC 1847840. PMID 17425406.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000198075 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10783263-3] Freimuth RR, Raftogianis RB, Wood TC, Moon E, Kim UJ, Xu J, Siciliano MJ, Weinshilboum RM (Jul 2000). "Human sulfotransferases SULT1C1 and SULT1C2: cDNA characterization, gene cloning, and chromosomal localization". Genomics. 65 (2): 157–65. doi:10.1006/geno.2000.6150. PMID 10783263.

[pmid9852044-4] Sakakibara Y, Yanagisawa K, Katafuchi J, Ringer DP, Takami Y, Nakayama T, Suiko M, Liu MC (Jan 1999). "Molecular cloning, expression, and characterization of novel human SULT1C sulfotransferases that catalyze the sulfonation of N-hydroxy-2-acetylaminofluorene". J Biol Chem. 273 (51): 33929–35. doi:10.1074/jbc.273.51.33929. PMID 9852044.

[entrez-5] "Entrez Gene: SULT1C2 sulfotransferase family, cytosolic, 1C, member 2".

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References

Further reading