SULT1C3

SULT1C3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2H8K, 2REO
Identifiers
Aliases	SULT1C3, ST1C3, sulfotransferase family 1C member 3
External IDs	OMIM: 617151; MGI: 102928; HomoloGene: 56817; GeneCards: SULT1C3; OMA:SULT1C3 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	108,265,351 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	54,297,702 bp
RNA expression pattern
	Top expressed in
	testicle; ; duodenum; ; mucosa of transverse colon; ; rectum; ; gastric mucosa; ; body of stomach; ; mucosa of esophagus; ; kidney; ; prostate; ; human kidney;
	Top expressed in
	olfactory epithelium; ; retinal pigment epithelium; ; trachea; ; conjunctival fornix; ; zygote; ; secondary oocyte; ; submandibular gland; ; primary oocyte; ; sexually immature organism; ; hippocampal formation;
	More reference expression data
	n/a
Gene ontology
Molecular function	alcohol sulfotransferase activity; aryl sulfotransferase activity; sulfotransferase activity; transferase activity;
Cellular component	cytoplasm;
Biological process	sulfur compound metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	442038
	20888
	ENSG00000196228
	ENSMUSG00000023943
	Q6IMI6
	Q80VR3
	NM_001008743; NM_001320878
	NM_018751
	NP_001008743; NP_001307807
	NP_061221
	Wikidata
View/Edit Human	View/Edit Mouse

Sulfotransferase 1C3, also known as ST1C3, is an enzyme that in humans is encoded by the SULT1C3 gene.^[5]^[6]^[7]

Function

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members.^[5]

Clinical significance

ST1C3 sulfates large benzylic alcohols such as 1-hydroxymethyl-pyrene to chemically reactive mutagenic sulpho conjugates.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000196228 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000023943 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: sulfotransferase family".
^ Freimuth RR, Wiepert M, Chute CG, Wieben ED, Weinshilboum RM (2004). "Human cytosolic sulfotransferase database mining: identification of seven novel genes and pseudogenes". Pharmacogenomics J. 4 (1): 54–65. doi:10.1038/sj.tpj.6500223. PMID 14676822. S2CID 17481502.
^ Allali-Hassani A, Pan PW, Dombrovski L, Najmanovich R, Tempel W, Dong A, Loppnau P, Martin F, Thornton J, Thonton J, Edwards AM, Bochkarev A, Plotnikov AN, Vedadi M, Arrowsmith CH (May 2007). "Structural and chemical profiling of the human cytosolic sulfotransferases". PLOS Biol. 5 (5): e97. doi:10.1371/journal.pbio.0050097. PMC 1847840. PMID 17425406.
^ Meinl W, Donath C, Schneider H, Sommer Y, Glatt H (April 2008). "SULT1C3, an orphan sequence of the human genome, encodes an enzyme activating various promutagens". Food Chem. Toxicol. 46 (4): 1249–56. doi:10.1016/j.fct.2007.08.040. PMID 17936463.

External links

PDBe-KB provides an overview of all the structure information available in the PDB for Human Sulfotransferase 1C3 (SULT1C3)

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000196228 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000023943 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: sulfotransferase family".

[pmid14676822-6] Freimuth RR, Wiepert M, Chute CG, Wieben ED, Weinshilboum RM (2004). "Human cytosolic sulfotransferase database mining: identification of seven novel genes and pseudogenes". Pharmacogenomics J. 4 (1): 54–65. doi:10.1038/sj.tpj.6500223. PMID 14676822. S2CID 17481502.

[pmid17425406-7] Allali-Hassani A, Pan PW, Dombrovski L, Najmanovich R, Tempel W, Dong A, Loppnau P, Martin F, Thornton J, Thonton J, Edwards AM, Bochkarev A, Plotnikov AN, Vedadi M, Arrowsmith CH (May 2007). "Structural and chemical profiling of the human cytosolic sulfotransferases". PLOS Biol. 5 (5): e97. doi:10.1371/journal.pbio.0050097. PMC 1847840. PMID 17425406.

[pmid17936463-8] Meinl W, Donath C, Schneider H, Sommer Y, Glatt H (April 2008). "SULT1C3, an orphan sequence of the human genome, encodes an enzyme activating various promutagens". Food Chem. Toxicol. 46 (4): 1249–56. doi:10.1016/j.fct.2007.08.040. PMID 17936463.

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Function

Clinical significance

See also

References

External links