SPRR1A

SPRR1A
Identifiers
Aliases	SPRR1A, SPRK, small proline rich protein 1A
External IDs	OMIM: 182265; MGI: 106660; HomoloGene: 105698; GeneCards: SPRR1A; OMA:SPRR1A - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	152,985,814 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	92,393,202 bp
RNA expression pattern
	Top expressed in
	gums; ; gingival epithelium; ; mucosa of pharynx; ; body of tongue; ; human penis; ; buccal mucosa cell; ; oral cavity; ; vulva; ; amniotic fluid; ; superior surface of tongue;
	Top expressed in
	transitional epithelium of urinary bladder; ; lip; ; esophagus; ; pyloric antrum; ; mucous cell of stomach; ; skin of external ear; ; cervix; ; skin of back; ; hair follicle; ; skin of abdomen;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein-macromolecule adaptor activity; protein binding; structural molecule activity; structural constituent of skin epidermis;
Cellular component	cytoplasm; cornified envelope; cytosol;
Biological process	peptide cross-linking; keratinization; keratinocyte differentiation; epidermis development; cornification;
	Sources:Amigo / QuickGO
Orthologs
	6698
	20753
	ENSG00000169474
	ENSMUSG00000050359
	P35321
	Q62266
	NM_005987; NM_001199828
	NM_009264
	NP_001186757; NP_005978
	NP_033290
	Wikidata
View/Edit Human	View/Edit Mouse

Cornifin-A is a protein that in humans is encoded by the SPRR1A gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000169474 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000050359 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gibbs S, Fijneman R, Wiegant J, van Kessel AG, van De Putte P, Backendorf C (June 1993). "Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins". Genomics. 16 (3): 630–7. doi:10.1006/geno.1993.1240. PMID 8325635.
^ "Entrez Gene: SPRR1A small proline-rich protein 1A".

Greco MA, Lorand L, Lane WS, Baden HP, Parameswaran KN, Kvedar JC (February 1995). "The pancornulins: a group of small proline rich-related cornified envelope precursors with bifunctional capabilities in isopeptide bond formation". The Journal of Investigative Dermatology. 104 (2): 204–10. doi:10.1111/1523-1747.ep12612759. PMID 7829876.
Robinson PA, Marley JJ, High AS, Hume WJ (March 1994). "Differential expression of protease inhibitor and small proline-rich protein genes between normal human oral tissue and odontogenic keratocysts". Archives of Oral Biology. 39 (3): 251–9. doi:10.1016/0003-9969(94)90051-5. PMID 8018055.
Fujimoto W, Nakanishi G, Arata J, Jetten AM (February 1997). "Differential expression of human cornifin alpha and beta in squamous differentiating epithelial tissues and several skin lesions". The Journal of Investigative Dermatology. 108 (2): 200–4. doi:10.1111/1523-1747.ep12334240. PMID 9008234.
Robinson NA, Lapic S, Welter JF, Eckert RL (May 1997). "S100A11, S100A10, annexin I, desmosomal proteins, small proline-rich proteins, plasminogen activator inhibitor-2, and involucrin are components of the cornified envelope of cultured human epidermal keratinocytes". The Journal of Biological Chemistry. 272 (18): 12035–46. doi:10.1074/jbc.272.18.12035. PMID 9115270.
Reddy SP, Konkin T, Wu R (December 1998). "Structure and organization of the genes encoding mouse small proline-rich proteins, mSPRR1A and 1B". Gene. 224 (1–2): 59–66. doi:10.1016/S0378-1119(98)00507-1. PMID 9931436.
Candi E, Tarcsa E, Idler WW, Kartasova T, Marekov LN, Steinert PM (March 1999). "Transglutaminase cross-linking properties of the small proline-rich 1 family of cornified cell envelope proteins. Integration with loricrin". The Journal of Biological Chemistry. 274 (11): 7226–37. doi:10.1074/jbc.274.11.7226. PMID 10066784.
Lee CH, Marekov LN, Kim S, Brahim JS, Park MH, Steinert PM (July 2000). "Small proline-rich protein 1 is the major component of the cell envelope of normal human oral keratinocytes". FEBS Letters. 477 (3): 268–72. doi:10.1016/S0014-5793(00)01806-8. PMID 10908733.
Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Cabral A, Voskamp P, Cleton-Jansen AM, South A, Nizetic D, Backendorf C (June 2001). "Structural organization and regulation of the small proline-rich family of cornified envelope precursors suggest a role in adaptive barrier function". The Journal of Biological Chemistry. 276 (22): 19231–7. doi:10.1074/jbc.M100336200. PMID 11279051.
Bonilla IE, Tanabe K, Strittmatter SM (February 2002). "Small proline-rich repeat protein 1A is expressed by axotomized neurons and promotes axonal outgrowth". The Journal of Neuroscience. 22 (4): 1303–15. doi:10.1523/JNEUROSCI.22-04-01303.2002. PMC 6757578. PMID 11850458.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000169474 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000050359 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8325635-5] Gibbs S, Fijneman R, Wiegant J, van Kessel AG, van De Putte P, Backendorf C (June 1993). "Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins". Genomics. 16 (3): 630–7. doi:10.1006/geno.1993.1240. PMID 8325635.

[entrez-6] "Entrez Gene: SPRR1A small proline-rich protein 1A".

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References

Further reading