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Protein-coding gene in the species Homo sapiens
Snurportin1 is a protein that in humans is encoded by the SNUPN gene .[ 5] [ 6]
The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5, is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5'-2,2,7-terminal trimethylguanosine (m3G) cap structure of the U snRNA and the Sm core domain. The protein encoded by this gene interacts specifically with m3G-cap and functions as an snRNP-specific nuclear import receptor. Alternatively spliced transcript variants encoding the same protein have been identified for this gene.[ 6]
^ a b c GRCh38: Ensembl release 89: ENSG00000169371 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000055334 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Huber J, Cronshagen U, Kadokura M, Marshallsay C, Wada T, Sekine M, Luhrmann R (Sep 1998). "Snurportin1, an m3G-cap-specific nuclear import receptor with a novel domain structure" . EMBO J . 17 (14): 4114–26. doi :10.1093/emboj/17.14.4114 . PMC 1170744 PMID 9670026 . ^ a b "Entrez Gene: SNUPN snurportin 1" .
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