SPDYA

SPDYA
Identifiers
Aliases	SPDYA, RINGO3, RINGOA, SPDY1, SPY1, speedy/RINGO cell cycle regulator family member A
External IDs	OMIM: 614029; MGI: 1918141; HomoloGene: 16357; GeneCards: SPDYA; OMA:SPDYA - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	28,850,611 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	71,896,528 bp
RNA expression pattern
	Top expressed in
	left testis; ; right testis; ; sperm; ; testicle; ; Achilles tendon; ; gonad; ; left ovary; ; granulocyte; ; right ovary; ; mucosa of transverse colon;
	Top expressed in
	spermatocyte; ; spermatid; ; seminiferous tubule; ; Stroma of ovary; ; ooblast; ; lumbar subsegment of spinal cord; ; morula; ; embryo; ; tail of embryo; ; ventricular zone;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein kinase binding; protein kinase activator activity;
Cellular component	nucleus; nucleoplasm;
Biological process	multicellular organism development; cell cycle; positive regulation of cyclin-dependent protein serine/threonine kinase activity; male meiotic nuclear division; positive regulation of cell population proliferation; cellular response to DNA damage stimulus; activation of protein kinase activity; positive regulation of protein kinase activity; G1/S transition of mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	245711
	70891
	ENSG00000163806
	ENSMUSG00000052525
	Q5MJ70
	Q5IBH7
	NM_182756; NM_001008779; NM_001142634
	NM_001142631; NM_029254
	NP_001008779; NP_001136106; NP_877433
	NP_001136103; NP_083530
	Wikidata
View/Edit Human	View/Edit Mouse

Speedy protein A is a protein that in humans is encoded by the SPDYA gene.^[5]^[6]^[7]^[8]

Interactions

SPDYA has been shown to interact with CDKN1B.^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163806 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000052525 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Porter LA, Dellinger RW, Tynan JA, Barnes EA, Kong M, Lenormand JL, Donoghue DJ (Apr 2002). "Human Speedy: a novel cell cycle regulator that enhances proliferation through activation of Cdk2". The Journal of Cell Biology. 157 (3): 357–66. doi:10.1083/jcb.200109045. PMC 2173287. PMID 11980914.
^ Barnes EA, Porter LA, Lenormand JL, Dellinger RW, Donoghue DJ (Jul 2003). "Human Spy1 promotes survival of mammalian cells following DNA damage". Cancer Research. 63 (13): 3701–7. PMID 12839962.
^ Cheng A, Xiong W, Ferrell JE, Solomon MJ (Jan 2005). "Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins". Cell Cycle. 4 (1): 155–65. doi:10.4161/cc.4.1.1347. PMID 15611625.
^ "Entrez Gene: SPDYA speedy homolog A (Drosophila)".
^ Porter LA, Kong-Beltran M, Donoghue DJ (Sep 2003). "Spy1 interacts with p27Kip1 to allow G1/S progression". Molecular Biology of the Cell. 14 (9): 3664–74. doi:10.1091/mbc.E02-12-0820. PMC 196558. PMID 12972555.

Porter LA, Kong-Beltran M, Donoghue DJ (Sep 2003). "Spy1 interacts with p27Kip1 to allow G1/S progression". Molecular Biology of the Cell. 14 (9): 3664–74. doi:10.1091/mbc.E02-12-0820. PMC 196558. PMID 12972555.
Gastwirt RF, Slavin DA, McAndrew CW, Donoghue DJ (Nov 2006). "Spy1 expression prevents normal cellular responses to DNA damage: inhibition of apoptosis and checkpoint activation". The Journal of Biological Chemistry. 281 (46): 35425–35. doi:10.1074/jbc.M604720200. PMID 16951407.
McAndrew CW, Gastwirt RF, Meyer AN, Porter LA, Donoghue DJ (Aug 2007). "Spy1 enhances phosphorylation and degradation of the cell cycle inhibitor p27". Cell Cycle. 6 (15): 1937–45. doi:10.4161/cc.6.15.4520. PMID 17671428.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163806 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000052525 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11980914-5] Porter LA, Dellinger RW, Tynan JA, Barnes EA, Kong M, Lenormand JL, Donoghue DJ (Apr 2002). "Human Speedy: a novel cell cycle regulator that enhances proliferation through activation of Cdk2". The Journal of Cell Biology. 157 (3): 357–66. doi:10.1083/jcb.200109045. PMC 2173287. PMID 11980914.

[pmid12839962-6] Barnes EA, Porter LA, Lenormand JL, Dellinger RW, Donoghue DJ (Jul 2003). "Human Spy1 promotes survival of mammalian cells following DNA damage". Cancer Research. 63 (13): 3701–7. PMID 12839962.

[pmid15611625-7] Cheng A, Xiong W, Ferrell JE, Solomon MJ (Jan 2005). "Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins". Cell Cycle. 4 (1): 155–65. doi:10.4161/cc.4.1.1347. PMID 15611625.

[entrez-8] "Entrez Gene: SPDYA speedy homolog A (Drosophila)".

[pmid12972555-9] Porter LA, Kong-Beltran M, Donoghue DJ (Sep 2003). "Spy1 interacts with p27Kip1 to allow G1/S progression". Molecular Biology of the Cell. 14 (9): 3664–74. doi:10.1091/mbc.E02-12-0820. PMC 196558. PMID 12972555.

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Interactions

References

Further reading