From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Small integral membrane protein (SMIM) 20 is a protein that in humans is encoded by the SMIM20 gene .[ 5] prohormone to the peptide hormone phoenixin which was discovered for the first time in 2013 in rodent sensory ganglia.[ 6]
In the study of the evolution of nervous systems , SMIM20 together with NUCB2 have been found to have deep homology across all lineages that preceded creatures with central nervous systems, bilaterians , cnidarians , ctenophores , and sponges as well as in choanoflagellates.[ 7] [ 8]
^ a b c GRCh38: Ensembl release 89: ENSG00000250317 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000061461 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Entrez Gene: Small integral membrane protein 20" . Retrieved 2014-02-05 .^ Yosten GL, Lyu RM, Hsueh AJ, Avsian-Kretchmer O, Chang JK, Tullock CW, et al. (February 2013). "A novel reproductive peptide, phoenixin" . Journal of Neuroendocrinology . 25 (2): 206– 215. doi :10.1111/j.1365-2826.2012.02381.x . PMC 3556183 PMID 22963497 . ^ Yañez-Guerra LA, Thiel D, Jékely G (April 2022). O'Connell M (ed.). "Premetazoan Origin of Neuropeptide Signaling" . Molecular Biology and Evolution . 39 (4): msac051. doi :10.1093/molbev/msac051 . PMC 9004410 PMID 35277960 . ^ Callier V (3 June 2022). "Brain-Signal Proteins Evolved Before Animals Did" . Quanta Magazine . Retrieved 2022-06-03 .
