SMARCD2

SMARCD2
Identifiers
Aliases	SMARCD2, BAF60B, CRACD2, Rsc6p, PRO2451, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2, SGD2
External IDs	OMIM: 601736; MGI: 1933621; HomoloGene: 20671; GeneCards: SMARCD2; OMA:SMARCD2 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	63,843,065 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	106,163,798 bp
RNA expression pattern
	Top expressed in
	skin of abdomen; ; skin of leg; ; body of pancreas; ; gastric mucosa; ; body of stomach; ; minor salivary glands; ; left uterine tube; ; ectocervix; ; cerebellar hemisphere; ; tibial nerve;
	Top expressed in
	Ileal epithelium; ; conjunctival fornix; ; renal corpuscle; ; medullary collecting duct; ; hair follicle; ; Paneth cell; ; lacrimal gland; ; condyle; ; fossa; ; internal carotid artery;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding; nucleosomal DNA binding; transcription coactivator activity; protein binding;
Cellular component	SWI/SNF complex; nucleus; nucleoplasm; protein-containing complex;
Biological process	regulation of transcription by RNA polymerase II; chromatin remodeling; nucleosome disassembly; regulation of transcription, DNA-templated; transcription, DNA-templated; chromatin organization; positive regulation of nucleic acid-templated transcription;
	Sources:Amigo / QuickGO
Orthologs
	6603
	83796
	ENSG00000108604
	ENSMUSG00000078619
	Q92925
	Q99JR8
	NM_001098426; NM_003077; NM_001330439; NM_001330440
	NM_001130187; NM_031878
	NP_001091896; NP_001317368; NP_001317369
	NP_001123659; NP_114084
	Wikidata
View/Edit Human	View/Edit Mouse

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 is a protein in humans that is encoded by the SMARCD2 gene.^[5]^[6]^[7]

The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and has sequence similarity to the yeast Swp73 protein.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000108604 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000078619 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wang W, Xue Y, Zhou S, Kuo A, Cairns BR, Crabtree GR (Nov 1996). "Diversity and specialization of mammalian SWI/SNF complexes". Genes Dev. 10 (17): 2117–30. doi:10.1101/gad.10.17.2117. PMID 8804307.
^ Ring HZ, Vameghi-Meyers V, Wang W, Crabtree GR, Francke U (Sep 1998). "Five SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin (SMARC) genes are dispersed in the human genome". Genomics. 51 (1): 140–3. doi:10.1006/geno.1998.5343. PMID 9693044.
^ ^a ^b "Entrez Gene: SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2".

Wang W, Côté J, Xue Y, et al. (1996). "Purification and biochemical heterogeneity of the mammalian SWI-SNF complex". EMBO J. 15 (19): 5370–82. doi:10.1002/j.1460-2075.1996.tb00921.x. PMC 452280. PMID 8895581.
Surabhi RM, Daly LD, Cattini PA (1999). "Evidence for evolutionary conservation of a physical linkage between the human BAF60b, a subunit of SWI/SNF complex, and thyroid hormone receptor interacting protein-1 genes on chromosome 17". Genome. 42 (3): 545–9. doi:10.1139/gen-42-3-545. PMID 10382302.
Bochar DA, Wang L, Beniya H, et al. (2000). "BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling to breast cancer". Cell. 102 (2): 257–65. doi:10.1016/S0092-8674(00)00030-1. PMID 10943845. S2CID 6500100.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Nie Z, Yan Z, Chen EH, et al. (2003). "Novel SWI/SNF chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner". Mol. Cell. Biol. 23 (8): 2942–52. doi:10.1128/MCB.23.8.2942-2952.2003. PMC 152562. PMID 12665591.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000108604 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000078619 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8804307-5] Wang W, Xue Y, Zhou S, Kuo A, Cairns BR, Crabtree GR (Nov 1996). "Diversity and specialization of mammalian SWI/SNF complexes". Genes Dev. 10 (17): 2117–30. doi:10.1101/gad.10.17.2117. PMID 8804307.

[pmid9693044-6] Ring HZ, Vameghi-Meyers V, Wang W, Crabtree GR, Francke U (Sep 1998). "Five SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin (SMARC) genes are dispersed in the human genome". Genomics. 51 (1): 140–3. doi:10.1006/geno.1998.5343. PMID 9693044.

[entrez-7] "Entrez Gene: SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2".

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References

Further reading