SERINC3

SERINC3
Identifiers
Aliases	SERINC3, AIGP1, DIFF33, SBBI99, TDE, TDE1, TMS-1, serine incorporator 3
External IDs	OMIM: 607165; MGI: 1349457; HomoloGene: 38230; GeneCards: SERINC3; OMA:SERINC3 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	44,522,085 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	163,487,051 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; tendon of biceps brachii; ; Pons; ; internal globus pallidus; ; Brodmann area 23; ; middle temporal gyrus; ; superior frontal gyrus; ; stromal cell of endometrium; ; postcentral gyrus; ; prefrontal cortex;
	Top expressed in
	lobe of prostate; ; seminal vesicula; ; stroma of bone marrow; ; left lung lobe; ; blood; ; Paneth cell; ; median eminence; ; parotid gland; ; Gonadal ridge; ; crypt of lieberkuhn of small intestine;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	L-serine transmembrane transporter activity;
Cellular component	integral component of membrane; Golgi membrane; Golgi apparatus; membrane; cytoplasm; perinuclear region of cytoplasm; plasma membrane;
Biological process	phosphatidylserine metabolic process; detection of virus; innate immune response; defense response to virus; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; sphingolipid metabolic process; L-serine transport; immune system process; L-serine biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	10955
	26943
	ENSG00000132824
	ENSMUSG00000017707
	Q13530
	Q9QZI9
	NM_198941; NM_006811
	NM_012032
	NP_006802; NP_945179
	NP_036162
	Wikidata
View/Edit Human	View/Edit Mouse

Serine incorporator 3 is a protein that in humans is encoded by the SERINC3 gene.^[5]^[6] It has been demonstrated that SERINC3 acts as a retrovirus restriction factor. ^[7]^[8]^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000132824 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000017707 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bossolasco M, Lebel M, Lemieux N, Mes-Masson AM (November 1999). "The human TDE gene homologue: localization to 20q13.1-13.3 and variable expression in human tumor cell lines and tissue". Molecular Carcinogenesis. 26 (3): 189–200. doi:10.1002/(SICI)1098-2744(199911)26:3<189::AID-MC8>3.0.CO;2-T. PMID 10559794. S2CID 19505445.
^ "Entrez Gene: SERINC3 serine incorporator 3".
^ Rosa A, Chande A, Ziglio S, De Sanctis V, Bertorelli R, Goh SL, McCauley SM, Nowosielska A, Antonarakis SE, Luban J, Santoni FA, Pizzato M (October 2015). "HIV-1 Nef promotes infection by excluding SERINC5 from virion incorporation". Nature. 526 (7572): 212–7. Bibcode:2015Natur.526..212R. doi:10.1038/nature15399. PMC 4861059. PMID 26416734.
^ Chande A, Cuccurullo EC, Rosa A, Ziglio S, Carpenter S, Pizzato M (November 2016). "S2 from equine infectious anemia virus is an infectivity factor which counteracts the retroviral inhibitors SERINC5 and SERINC3". Proceedings of the National Academy of Sciences of the United States of America. 113 (46): 13197–13202. doi:10.1073/pnas.1612044113. PMC 5135340. PMID 27803322.
^ Ramdas P, Bhardwaj V, Singh A, Vijay N, Chande A (2020-02-24). "Coevolution of retroviruses with SERINCs following whole-genome duplication divergence". bioRxiv. doi:10.1101/2020.02.24.962506.

Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O (September 1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID 7566098.
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Bossolasco M, Veillette F, Bertrand R, Mes-Masson AM (August 2006). "Human TDE1, a TDE1/TMS family member, inhibits apoptosis in vitro and stimulates in vivo tumorigenesis". Oncogene. 25 (33): 4549–58. doi:10.1038/sj.onc.1209488. PMID 16547497. S2CID 24696947.

This article on a gene on human chromosome 20 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000132824 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000017707 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10559794-5] Bossolasco M, Lebel M, Lemieux N, Mes-Masson AM (November 1999). "The human TDE gene homologue: localization to 20q13.1-13.3 and variable expression in human tumor cell lines and tissue". Molecular Carcinogenesis. 26 (3): 189–200. doi:10.1002/(SICI)1098-2744(199911)26:3<189::AID-MC8>3.0.CO;2-T. PMID 10559794. S2CID 19505445.

[entrez-6] "Entrez Gene: SERINC3 serine incorporator 3".

[7] Rosa A, Chande A, Ziglio S, De Sanctis V, Bertorelli R, Goh SL, McCauley SM, Nowosielska A, Antonarakis SE, Luban J, Santoni FA, Pizzato M (October 2015). "HIV-1 Nef promotes infection by excluding SERINC5 from virion incorporation". Nature. 526 (7572): 212–7. Bibcode:2015Natur.526..212R. doi:10.1038/nature15399. PMC 4861059. PMID 26416734.

[8] Chande A, Cuccurullo EC, Rosa A, Ziglio S, Carpenter S, Pizzato M (November 2016). "S2 from equine infectious anemia virus is an infectivity factor which counteracts the retroviral inhibitors SERINC5 and SERINC3". Proceedings of the National Academy of Sciences of the United States of America. 113 (46): 13197–13202. doi:10.1073/pnas.1612044113. PMC 5135340. PMID 27803322.

[9] Ramdas P, Bhardwaj V, Singh A, Vijay N, Chande A (2020-02-24). "Coevolution of retroviruses with SERINCs following whole-genome duplication divergence". bioRxiv. doi:10.1101/2020.02.24.962506.

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References

Further reading