rs1799913
| SNP: rs1799913 | |
|---|---|
| Name(s) | A779C |
| Gene | TPH1 |
| Chromosome | 11 |
| Region | Intron 7 |
| External databases | |
| Ensembl | Human SNPView |
| dbSNP | 1799913 |
| HapMap | 1799913 |
| SNPedia | 1799913 |
| SzGene | Meta-analysis Overview |
In genetics, rs1799913, also called A779C, is a gene variation—a single nucleotide polymorphism (SNP)— in the TPH1 gene. It is located in intron 7.[1]
The SNP association with schizophrenia has been examined in several studies, though as of 2007 with no definitive conclusion.[2]
One study has found that the SNP may be associated with heroin addiction.[3] Other study relate it to figural and numeric creativity.[4]
A218C (rs1800532) is another SNP in the same intron in the same gene.[1]
References
[edit]- ^ a b D. A. Nielsen, G. L. Jenkins, K. M. Stefanisko, K. K. Jefferson & D. Goldman (April 1997). "Sequence, splice site and population frequency distribution analyses of the polymorphic human tryptophan hydroxylase intron 7". Brain Research. Molecular Brain Research. 45 (1): 145–148. doi:10.1016/S0169-328X(96)00304-X. PMID 9105682.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ P. G. Sand (November 2007). "Comments on the paper by D. Li and L. He: Meta-analysis shows association between the tryptophan hydroxylase (TPH) gene and schizophrenia". Human Genetics. 122 (3–4): 409–411. doi:10.1007/s00439-007-0383-6. PMID 17653577. S2CID 13181665.
- ^ David A. Nielsen, Sandra Barral, Dmitri Proudnikov, Scott Kellogg, Ann Ho, Jurg Ott & Mary Jeanne Kreek (March 2008). "TPH2 and TPH1: association of variants and interactions with heroin addiction". Behavior Genetics. 38 (2): 133–50. doi:10.1007/s10519-007-9187-7. PMID 18181017. S2CID 2774846.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Reuter M, Roth S, Holve K & Hennig J. (2006). "Identification of first candidate genes for creativity: a pilot study". Brain Res. 1069 (1): 190–197. doi:10.1016/j.brainres.2005.11.046. PMID 16403463. S2CID 25365017.
{{cite journal}}: CS1 maint: multiple names: authors list (link)